Amifostine Trihydrate - 10mM in Water , CAS No.112901-68-5

CAS: 112901-68-5 Cat. No.: A420668 Formula: C₅H₁₅N₂O₃PS·3H₂O Peso molecolare: 268.27 Numero EC: 806-322-5

GRADE & PURITY 10mM in Water

Synonyms

Amifostine trihydrate|112901-68-5|Anifostine trihydrate|112901-68-5 (trihydrate)|M487QF2F4V|NSC 296961|S-(2-((3-aminopropyl)amino)ethyl) O,O-dihydrogen phosphorothioate trihydrate|Ethanethiol, 2-((3-aminopropyl)amino)-, dihydrogen phosphate (ester), trihy

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Application：

Amifostine may provide renal protection during PRRT using somatostatin analogs by mitigating radiation damage and reducing the absorbed kidney radiation dose. Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible.

Specifications

Sinonimi

Amifostine trihydrate | 112901-68-5 | Anifostine trihydrate | 112901-68-5 (trihydrate) | M487QF2F4V | NSC 296961 | S-(2-((3-aminopropyl)amino)ethyl) O,O-dihydrogen phosphorothioate trihydrate | Ethanethiol, 2-((3-aminopropyl)amino)-, dihydrogen phosphate (ester), trihy

Specifiche e purezza

10mM in Water

Meccanismi biochimici e fisiologici

Radioprotective agent. Selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy. Selectivity is due to preferential uptake by normal tissues and subsequent metabolic activation to 2-(3-aminopropyl)aminoethanethiol

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

Pubchem Sid

528769107

Sorrisi canonici

C(CN)CNCCSP(=O)(O)O.O.O.O

IUPAC Name

2-(3-aminopropylamino)ethylsulfanylphosphonic acid;trihydrate

InChIKey

TXQPXJKRNHJWAX-UHFFFAOYSA-N

INCHI

1S/C5H15N2O3PS.3H2O/c6-2-1-3-7-4-5-12-11(8,9)10;;;/h7H,1-6H2,(H2,8,9,10);3*1H2

Isomeri SMILES

C(CN)CNCCSP(=O)(O)O.O.O.O

WGK Germania

3

RTECS

TE6491000

Peso molecolare

268.27

Reaxy-Rn

13570647

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13570647&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organophosphorus compounds
    • Classe Organothiophosphorus compounds

• Kingdom: Organic compounds
• Superclass: Organophosphorus compounds
• Classe: Organothiophosphorus compounds
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Organothiophosphorus compounds
• Alternative Parents: Sulfenyl compounds Dialkylamines Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Sulfenyl compound - Secondary amine - Organothiophosphorus compound - Secondary aliphatic amine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Primary amine - Organosulfur compound - Organonitrogen compound - Primary aliphatic amine - Amine - Aliphatic acyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as organothiophosphorus compounds. These are organic derivatives of thiophosphonic acid, thiophosphoric acid, dithiophosphoric acid, or phosphorotrithioic acid, or derivatives thereof. Thiophosphonic acid, dithiophosphoric acid, thiophosphoric acid, and phosphorotrithioic acid are thiophosphorus compounds with the formula OP(O)(=S), OP(S)(=S)O, OP(O)(=S)O, and OP(=S)(S)S, respectively.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Proprietà chimiche e fisiche

• Peso molecolare: 268.270 g/mol
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 7
• Exact Mass: 268.086 Da
• Monoisotopic Mass: 268.086 Da
• Topological Polar Surface Area: 124.000 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 152.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 4

XLogP3