Aminophylline - 10mM in DMSO , Adenosine receptor antagonist, CAS No.317-34-0, Adenosine receptor antagonist

CAS: 317-34-0 Cat. No.: A408079 Formula: C₁₆H₂₄N₁₀O₄ Peso molecolare: 420.43 Numero EC: 206-264-5

GRADE & PURITY 10mM in DMSO

Synonyms

Phyllocontin | 3,​9-​dihydro-​1,​3-​dimethyl-1H-​purine-​2,​6-​dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Aminophylline Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.
In vitro

In vivo

Cell Data

cell lines：UMSCC10B, UMSCC14B, UMSCC17B, UMSCC22B, and UMSCC35, UMSCC38 cell lines

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

Phyllocontin | 3,​9-​dihydro-​1,​3-​dimethyl-1H-​purine-​2,​6-​dione

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Meccanismo d'azione

Adenosine receptor antagonist

Nomi e identificatori

• Isomeri SMILES: CN1C2=C(C(=O)N(C1=O)C)NC=N2.CN1C2=C(C(=O)N(C1=O)C)NC=N2.C(CN)N
• WGK Germania: 3
• RTECS: XH5600000
• Numero UN: 2811
• Peso molecolare: 420.43
• Reaxy-Rn: 5784418
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5784418&ln=

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 100 mg/mL Water: Insoluble; Ethanol: 100 mg/mL
• Punto di fusione (°C): 269-270°C

Riferimenti

1. Chaozhi Ma, Liyuan Zou, Yu Xia, Yijun Tu, Daquan Xue, Yanfang Yang, Dan Liu, Yanwen Liu, Hezhen Wu, Hanxiong Dan, Pengtao You.  (2018)  Extracts of Coleus forskohlii relieves cough and asthma symptoms via modulating inflammation and the extracellular matrix.  JOURNAL OF CELLULAR BIOCHEMISTRY,  120  (6): (9648-9655).  [PMID:30520122] [10.1002/jcb.28243]

2. Xingxing Duan, Bufan Yu, Guangrong Jin, Dengliang Zhang, Jiangshan Chen, Dongge Ma.  (2024)  Modification of mixed-halide quasi-2D perovskites by aminophylline towards efficient and spectrally stable blue light-emitting diodes with low efficiency roll-off.  Journal of Materials Chemistry C,      [PMID:] [10.1039/D4TC04214J]