Anatabine dicitrate - 10mM in DMSO , CAS No.A661702(DMSO)

CAS: A661702(DMSO) Cat. No.: A661702 Formula: C₂₂H₂₈N₂O₁₄ Peso molecolare: 544.46

QUALITÀ & PUREZZA 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. Anatabine dicitrate is a potent α4β2 nAChR agonist. Anatabine dicitrate inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid pre

IC50& Target:NF-κB Amyloid-β (Aβ) α4β2 nAChR

In Vitro:Anatabine (600 μg/mL; 24 hours; SHSY-5Y cells) treatment shows an inhibition of p65 NF-κB phosphorylation. Anatabine (500-1000μg/mL; 30 minutes; SHSY-5Y cells) treatment fully prevents the increase in BACE-1 mRNA levels induced by TNF-α. After 24 hou

In Vivo:Anatabine (0.5-2mg/kg; intraperitoneal injection; daily; for 4 days; transgenic mouse) treatment significantly lowers brain soluble Aβ 1-40 and Aβ 1-42 levels in a transgenic mouse model of Alzheimer's disease. MCE has not independently confirmed th

Biological Activity:Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. Anatabine dicitrate is a potent α4β2 nAChR agonist. Anatabine dicitrate inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid pre

Specifiche

Specifiche e purezza

10mM in DMSO

Condizioni di conservazione di stoccaggio

Desiccated,Store at -80°C

Spedito in

Dry ice packs + Cold packs

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Tipo di azione

AGONIST

Nomi e identificatori

Peso molecolare

544.46