Antipyrine - 10mM in DMSO , Cyclooxygenase-1 inhibitor, CAS No.60-80-0, Cyclooxygenase-1 inhibitor

CAS: 60-80-0 Cat. No.: A408977 Molecular Weight: 188.23 Beilstein Registry Number: 157775 EC Number: 200-486-6
AVAILABLE TO ORDER
GRADE & PURITY 10mM in DMSO
Synonyms
Phenazone | 1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
1ml
A408977-1ml
2
$39.90
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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 5 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

Antipyrine Antipyrine (Phenazone) is an analgesic and antipyretic agent; selective COX-3 inhibitor.
In vitro

Antipyrine is an analgesic and antipyretic.

In vivo


Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥99%

Specifications

Synonyms
Phenazone | 1, 5-dimethyl-2-phenyl-1, 2-dihydropyrazol-3-one
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Antipyrine (Phenazone) is an analgesic and antipyretic agent; selective COX-3 inhibitor.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Mechanism of action
Cyclooxygenase-1 inhibitor
Product Properties
ALogP0.4
Names and Identifiers
Isomeric SMILES CC1=CC(=O)N(N1C)C2=CC=CC=C2
WGK Germany 1
RTECS CD2450000
Molecular Weight 188.23
Beilstein 157775
Reaxy-Rn 157775
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=157775&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Associated Targets(Human)
NAPRT Tchem Nicotinate phosphoribosyltransferase (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
Refractive Index1.5697
Boil Point(°C)319°C
Melt Point(°C)114°C
Documents & Articles
Citations of This Product
References
1. Shilong Jiang, Song Cheng, Jiashun Cao, Cailiang Yue, Jianglei Xiong, Cong Jiang, Hongzhan Cai, Jianhua Wu.  (2023)  Monodispersed Co-N3 loaded carbon nitride mediated peroxymonosulfate activation for rapid degradation of trace urea via singlet oxygen.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.147526]
2. Yuqiong Gao, Han Ning, Yanyan Rao, Kexuan Li, Chaole Zeng, Naiyun Gao.  (2023)  Efficient elimination of phenazone by an electro-assisted Fe3+-EDDS/PS process at neutral pH: Kinetics, mechanistic insights and toxicity evaluation.  CHEMOSPHERE,      [PMID:37028723] [10.1016/j.chemosphere.2023.138598]
3. Wanbao Wu, Yihong Liang, Deping Li, Yiyang Bo, Dong Wu, Lijie Ci, Mingyu Li, Jiaheng Zhang.  (2022)  A Competitive Solvation of Ternary Eutectic Electrolytes Tailoring the Electrode/Electrolyte Interphase for Lithium Metal Batteries.  ACS Nano,      [PMID:36040142] [10.1021/acsnano.2c05016]
4. Chen Junyang, Xiang Pan, Duro-Castano Aroa, Cai Huawei, Guo Bin, Liu Xiqin, Yu Yifan, Lui Su, Luo Kui, Ke Bowen, Ruiz-Pérez Lorena, Gong Qiyong, Tian Xiaohe, Battaglia Giuseppe.  (2025)  Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport.  Signal Transduction and Targeted Therapy,  10  (1): (1-12).  [PMID:41052971] [10.1038/s41392-025-02426-1]
5. Fu Zeng, Lian Huang, Ding Han, Renjie Liu, Kongjia Zhang, Yuwen Su, Tong Su, Yarong Lin, Jianbo Xiu.  (2025)  An Improved SHANEL Procedure for Clearing and Staining Brain Tissue from Multiple Species.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  26  (8): (3569).  [PMID:40332069] [10.3390/ijms26083569]
Solution Calculators
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