Atomoxetine HCl - 10mM in DMSO , Norepinephrine transporter inhibitor, CAS No.82248-59-7, Norepinephrine transporter inhibitor

CAS: 82248-59-7 Cat. No.: A407994 Formula: C₁₇H₂₁NO·HCl Peso molecolare: 291.82 Numero EC: 629-925-3

GRADE & PURITY 10mM in DMSO

Synonyms

LY 139603 HCl | (R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine hydrochloride

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Atomoxetine HCl Atomoxetine (LY 139603) is a selective norepinephrine (NE) transporter inhibitor with K i of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.
In vitro

Atomoxetine is a selective norepinephrine reuptake inhibitor with K_i of 5 nM, compared with 77 and 1451 nM for binding to serotonin and dopamine transporters.

In vivo

In microdialysis studies, atomoxetine increases extracellular (EX) levels of NE in prefrontal cortex (PFC) 3-fold, but does not alter 5-HT_EX levels. Atomoxetine also increases DA_EX concentrations in PFC 3-fold, but does not alter DA_EX in striatum or nucleus accumbens. Atomoxetine increases Fos by 3.7-fold in PFC, but not in the striatum or nucleus accumbens. Atomoxetine selectively inhibits the presynaptic uptake of norepinephrine in adrenergic neurons in animals, and has activity in animal models of depression.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

LY 139603 HCl | (R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine hydrochloride

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Atomoxetine (LY 139603) is a selective norepinephrine (NE) transporter inhibitor with K_i of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Meccanismo d'azione

Norepinephrine transporter inhibitor

Nomi e identificatori

• Isomeri SMILES: CC1=CC=CC=C1O[C@H](CCNC)C2=CC=CC=C2.Cl
• WGK Germania: 1
• CAS alternativo: 83015-26-3
• Peso molecolare: 291.82
• Reaxy-Rn: 6691924
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6691924&ln=

Proprietà chimiche e fisiche

• Rotazione specifica [α]: -42° (C=1,MeOH)
• Punto di fusione (°C): 167.0 - 171.0 °C

Riferimenti

1. Jieqing Feng, Qisheng Zhong, Ting Zhou.  (2022)  Online Pressure Change Focusing-Supercritical Fluid Selective Extraction Chromatography for Analyzing Chiral Drugs in Microliter-Scale Plasma Samples.  ANALYTICAL CHEMISTRY,      [PMID:36356211] [10.1021/acs.analchem.2c03892]

2. Yutong You, Xu Wang, Kaiqi Ma, Jiaru Li, Ying Peng, Jiang Zheng.  (2021)  Metabolic Activation of Atomoxetine Mediated by Cytochrome P450 2D6.  CHEMICAL RESEARCH IN TOXICOLOGY,      [PMID:34431675] [10.1021/acs.chemrestox.1c00216]