AWD 131-138 - 10mM in DMSO , CAS No.188116-07-6

CAS: 188116-07-6 Cat. No.: A422296 Formula: C₁₃H₁₄ClN₃O₂ Peso molecolare: 279.72 Numero EC: 692-636-6

GRADE & PURITY 10mM in DMSO

Synonyms

Imepitoin|188116-07-6|AWD 131-138|Pexion|Imepition|Imepitoin [INN]|2H-Imidazol-2-one, 1-(4-chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-|AWD131-138|UNII-19V39682LI|19V39682LI|ADD-233089|1-(4-Chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one|AWD

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

AWD 131-138 AWD 131-138 (Imepitoin, ELB-138) is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy. AWD 131-138 (Imepitoin) is an antiepileptic and antianxietic drug, AWD 131-138 can stimulate different recombinant isoforms of the rat GABA(A) receptor through the benzodiazepine binding site.

Specifications

Sinonimi

Imepitoin | 188116-07-6 | AWD 131-138 | Pexion | Imepition | Imepitoin [INN] | 2H-Imidazol-2-one, 1-(4-chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)- | AWD131-138 | UNII-19V39682LI | 19V39682LI | ADD-233089 | 1-(4-Chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one | AWD

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

AWD 131-138 (Imepitoin, ELB-138) is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy. AWD 131-138 (Imepitoin) is an antiepileptic and antianxietic drug, AWD 131-138 can sti

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

AGONIST

Proprietà del prodotto

• ALogP: 1.44
• hba_count: 3
• Legame rotabile: 2

Nomi e identificatori

• Pubchem Sid: 528763181
• Sorrisi canonici: C1COCCN1C2=NC(=O)N(C2)C3=CC=C(C=C3)Cl
• IUPAC Name: 3-(4-chlorophenyl)-5-morpholin-4-yl-4H-imidazol-2-one
• InChIKey: IQHYCZKIFIHTAI-UHFFFAOYSA-N
• INCHI: 1S/C13H14ClN3O2/c14-10-1-3-11(4-2-10)17-9-12(15-13(17)18)16-5-7-19-8-6-16/h1-4H,5-9H2
• Isomeri SMILES: C1COCCN1C2=NC(=O)N(C2)C3=CC=C(C=C3)Cl
• Peso molecolare: 279.72
• Reaxy-Rn: 8917426
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8917426&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Halobenzenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Halobenzenes
• Intermediate Tree Nodes: Not available
• Direct Parent: Chlorobenzenes
• Alternative Parents: Morpholines Aryl chlorides Imidazolines Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Dialkyl ethers Carboximidamides Carboxamidines Azacyclic compounds Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds Amines
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Chlorobenzene - Aryl chloride - Aryl halide - Morpholine - Oxazinane - 3-imidazoline - Amidine - Carboxylic acid amidine - Dialkyl ether - Ether - Oxacycle - Azacycle - Carboximidamide - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organoheterocyclic compound - Hydrocarbon derivative - Organic oxygen compound - Organohalogen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Carbonyl group - Amine - Organic oxide - Organic nitrogen compound - Aromatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as chlorobenzenes. These are compounds containing one or more chlorine atoms attached to a benzene moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Sensibilità: Sensitive to light
• DMSO (mg/mL) Solubilità massima: 30
• DMSO (mM) Solubilità massima: 107.250107250107
• Acqua (mg/mL) Solubilità massima: ＜1
• Peso molecolare: 279.720 g/mol
• XLogP3: 1.200
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 279.077 Da
• Monoisotopic Mass: 279.077 Da
• Topological Polar Surface Area: 45.100 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 374.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1