AZ13705339 hemihydrate - 10mM in DMSO , CAS No.A661682(DMSO)

CAS: A661682(DMSO) Cat. No.: A661682 Molecular Weight: 638.77

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

AZ13705339 hemihydrate is a highly potent and selective PAK1 inhibitor with IC 50 s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 hemihydrate has binding affinities to PAK1 and PAK2 , with K d s of 0.28 nM and 0.32 nM, respectively. AZ

IC50& Target:PAK2 0.32 nM (Kd) PAK1 0.28 nM (Kd) PAK1 0.33 nM (IC 50 ) pPAK1 59 nM (IC 50 )

In Vitro:AZ13705339 (1 μM) hemihydrate inhibits αIgM-controlled adhesion and not PMA-induced adhesion in Namalwa cells. AZ13705339 (300 nM, 30 min) prevents Siglec-8 engagement-induced eosinophil death. MCE has not independently confirmed the accuracy of

In Vivo:AZ13705339 hemihydrate (100mg/kg, P.O.) has moderate clearance and oral C max of 7.7 μM in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Biological Activity:AZ13705339 hemihydrate is a highly potent and selective PAK1 inhibitor with IC 50 s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 hemihydrate has binding affinities to PAK1 and PAK2 , with K d s of 0.28 nM and 0.32 nM, respectively. AZ

Specifications

Specifications & Purity

10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Molecular Weight: 638.77