Azelnidipine - 10mM in DMSO , Voltage-gated L-type calcium channel blocker, CAS No.123524-52-7, Voltage-gated L-type calcium channel blocker

CAS: 123524-52-7 Cat. No.: A408670 Formula: C₃₃H₃₄N₄O₆ Peso molecolare: 582.65 Numero EC: 634-143-0

GRADE & PURITY 10mM in DMSO

Synonyms

UR-12592 | 3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Azelnidipine Azelnidipine (UR-12592) is a dihydropyridine calcium channel blocker.
In vitro

Azelnidipine is a newly developed long-acting calcium channel blocker with unique pharmacological features, e.g. cardiac slowing action and high affinity to vascular tissues, which distinguishes itself from other calcium channel blockers. Azelnidipine, thus, became a new generation of calcium channel blocker that can be used for the treatment of hypertensive patients with or without potential ischemic heart diseases. Because this new calcium antagonist is highly lipid soluble, it is retained in the vascular wall after clearance from the blood and continues to elicit a hypotensive effect.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

UR-12592 | 3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Azelnidipine (UR-12592) is a dihydropyridine calcium channel blocker.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

BLOCKER

Meccanismo d'azione

Voltage-gated L-type calcium channel blocker

Proprietà del prodotto

• ALogP: 6

Nomi e identificatori

• Isomeri SMILES: CC1=C(C(C(=C(N1)N)C(=O)OC2CN(C2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC(C)C
• WGK Germania: 3
• RTECS: US7968332
• Peso molecolare: 582.65
• Reaxy-Rn: 7420123
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7420123&ln=

Riferimenti

1. Xiaofei Ma, Jing Cao, Juan Yu, Liangliang Cai.  (2022)  Evaluation of an ionic liquid chiral selector based on sulfobutylether-β-cyclodextrin in capillary electrophoresis.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2022.119782]

2. Yunong Li, Haixia Zhu, Jingbo Yang, Kehui Ke, Yanmei Zhu, Li Chen, Youyang Qu, Rui Suo, Xiujie Chen, Yulan Zhu.  (2018)  Discovering Proangiogenic Drugs in Ischemic Stroke Based on the Relationship between Protein Domain and Drug Substructure.  ACS Chemical Neuroscience,      [PMID:30346717] [10.1021/acschemneuro.8b00381]

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 123524-52-7, the molecular formula is C33H34N4O6, and the molecular weight is 582.65 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.