Azvudine - ≥98% , Human immunodeficiency virus type 1 reverse transcriptase inhibitor, CAS No.1011529-10-4, Human immunodeficiency virus type 1 reverse transcriptase inhibitor

CAS: 1011529-10-4 Cat. No.: A648672 Formula: C₉H₁₁FN₆O₄ Peso molecolare: 286.22 PubChem CID: 24769759

GRADE & PURITY ≥98%

Synonyms

RO-0622 | F86375 | 1011529-10-4 | 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine | 4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one | Azvudine | FNCRO-0622 | A848947 | DTXSID901027757 | AKOS040741284 |

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains.

Specifications

Sinonimi

RO-0622 | F86375 | 1011529-10-4 | 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine | 4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one | Azvudine | FNCRO-0622 | A848947 | DTXSID901027757 | AKOS040741284 |

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV , HBV and HCV . Azvudine exerts highly potent inhibition on HIV-1 (EC 50 s ranging from 0.03 to 6.92 nM) and HIV-2 (EC 50 s ranging from 0.018

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Meccanismo d'azione

Human immunodeficiency virus type 1 reverse transcriptase inhibitor

Purezza

≥98%

Proprietà del prodotto

ALogP

-0.8

Nomi e identificatori

Pubchem Sid

528763354

Sorrisi canonici

C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)F

IUPAC Name

4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

InChIKey

KTOLOIKYVCHRJW-XZMZPDFPSA-N

INCHI

1S/C9H11FN6O4/c10-5-6(18)9(3-17,14-15-12)20-7(5)16-2-1-4(11)13-8(16)19/h1-2,5-7,17-18H,3H2,(H2,11,13,19)/t5-,6-,7+,9+/m0/s1

Isomeri SMILES

C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@](O2)(CO)N=[N+]=[N-])O)F

CAS alternativo

1011529-10-4

PubChem CID

24769759

Termini MeSH

2'-deoxy-2'-beta-fluoro-4'-azidocytidine;4'-azido-2'-deoxy-2'-fluorocytidine;4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-5-((imino-l,5-azanylidene)amino)tetrahydrofuran-2-yl)pyrimidin-2-one;4-amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(

Peso molecolare

286.22

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Diazines
      • Subclass Pyrimidines and pyrimidine derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Diazines
• Subclass: Pyrimidines and pyrimidine derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrimidones
• Alternative Parents: Aminopyrimidines and derivatives Primary aromatic amines Hydropyrimidines Imidolactams Oxolanes Heteroaromatic compounds Secondary alcohols Azo compounds Azo imides Fluorohydrins Azacyclic compounds Oxacyclic compounds Hydrocarbon derivatives Organic zwitterions Organofluorides Organopnictogen compounds Primary alcohols Alkyl fluorides Organic salts Organic oxides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Aminopyrimidine - Pyrimidone - Hydropyrimidine - Imidolactam - Primary aromatic amine - Heteroaromatic compound - Oxolane - Azo compound - Azo imide - Fluorohydrin - Halohydrin - Secondary alcohol - Oxacycle - Azacycle - Organic zwitterion - Primary amine - Primary alcohol - Alkyl fluoride - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Alcohol - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Alkyl halide - Organic salt - Aromatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as pyrimidones. These are compounds that contain a pyrimidine ring, which bears a ketone. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

Homo sapiens (32628 Activities)

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MT2 (2907 Activities)

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MT4 (17854 Activities)

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HEK293 (82097 Activities)

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Obiettivi associati (non umani)

Rattus norvegicus (775804 Activities)

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Hepatitis B virus (7925 Activities)

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Human immunodeficiency virus 1 (70413 Activities)

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Hepatitis C virus (23859 Activities)

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SARS-CoV-2 (38078 Activities)

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: DMSO : 125 mg/mL (436.73 mM; Need ultrasonic)
• Peso molecolare: 286.220 g/mol
• XLogP3: -0.800
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 286.083 Da
• Monoisotopic Mass: 286.083 Da
• Topological Polar Surface Area: 123.000 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 533.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 1
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1