10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Panoramica
BA-53038B is a HBV core protein allosteric modulator (CpAM) , binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC 50 value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B
In Vitro
BA-53038B has antiviral activity for HBV with an EC 50 value of 3.32 μM. BA-53038B has cytotoxicity with CC 50 value of >100 μM. BA-53038B (5 μM; 48 h) induces the capsid/nucleocapsid mobility shift and reduced the amount of hypophosphorylated core protein. BA-53038B (0-20 μM; 2 or 6 days) inhibits HBV nucleocapsid assembly. BA-53038B (5 μM; 2 days) inhibits pgRNA encapsidation and consequentially reduces the amount of DNA-containing capsids and hypophosphorylated core protein. BA-53038B (2 μM; 6 h) modulates HBV capsid assembly by binding to the HAP pocket. BA-53038B has resistant effect with an EC 50 value of >10 μM on HBV capsid (HepG2 cells transiently transfected pHBV1.3/core-V124W). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: AML12HBV10 cells Concentration: 5 μM Incubation Time: 48 h Result: Reduced the amount of hypophosphorylated core protein and promoted the assembly of empty capsids with slow electrophoresis mobility. RT-PCRCell Line: AML12HBV10 and HepDES19 cells Concentration: 0-20 μM Incubation Time: 2 or 6 days Result: Inhibited HBV replication in both AML12HBV10 and HepDES19 cells.
IC50& Target:EC 50: 3.32 μM (HBV)
Specifications
Specifiche e purezza
10mM in DMSO
Meccanismi biochimici e fisiologici
BA-53038B is a HBV core protein allosteric modulator (CpAM) , binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC 50 value of 3.32 μM. BA-53038B can be used for the research
Condizioni di conservazione di stoccaggio
Store at -80°C
Spedito in
Dry ice packs + Cold packs
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
Tipo di azione
INHIBITOR
Nomi e identificatori
PubChem CID
138454763
Peso molecolare
249.74
Documentazione
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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