BBIQ - ≥97% , CAS No.1229024-57-0

CAS: 1229024-57-0 Cat. No.: B647614 Molecular Weight: 330.43

GRADE & PURITY ≥97%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

BBIQ is a imidazoquinoline compound and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC 50 of  59.1 nM for human TLR7 . BBIQ is a powerful vaccine adjuvant that enhances innate immune responses

In Vitro

BBIQ induces IFN-α in human PBMCs (520 pg/mL at 5 µg/mL). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In mice treated with Chloroquine (CQ) alone, parasite ( P. berghei ANKA) appearesd on Day 17 and all mice of this group died by Day 21. Whereas, mice treated with BBIQ along with CQ exhibits no appearance of parasite till Day 23. Frequencies of T cells (CD3+, CD4+and CD8+) and T regulatory cells (CD4+, CD25 +and FoxP3+) are lower in brain of BBIQ + CQ treated mice as compared to BBIQ alone and CQ alone treated mice on Day 10. Inhibition of infiltration of inflammatory T cells and activation of T helper and T cytotoxic cells against the parasite is observed in the mice treated with this combination therapy. Serum levels of IFN-γ and IL-12 are higher on same day in mice treated with BBIQ + CQ which reveals the generation of strong Th1 immune response in mice against the infection . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:TLR7 59.1 nM (EC 50 , Human TLR7)

Specifications

Specifications & Purity

≥97%

Biochemical and Physiological Mechanisms

BBIQ is a imidazoquinoline compound and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC 50 of u202f59.1u202fnM for human TLR7 . BBIQ is a powerful vaccine adjuvant that enhances innate immune responses.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Purity

≥97%

Names and Identifiers

• Molecular Weight: 330.43

Chemical and Physical Properties

• Solubility: DMSO : 16.67 mg/mL (50.45 mM; ultrasonic and warming and heat to 60°C)