10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
BI 689648 is a novel, highly selective aldosterone synthase inhibitor which can inhibit CYP11B1 and CYP11B2 with IC 50 s of 310 and 2.1 nM, respectively.
In Vitro
Compare with the FADs and LCI699, BI 689648 is highly selective in vitro , providing an IC 50 for CYP11B2 of 2.1 nM and a selectivity factor of 149 over CYP11B1. FAD286, by comparison, shows a similar IC 50 for CYP11B2 (2.5 nM); however, its greater potency against CYP11B1 (94 nM) results in a comparatively modest selectivity factor of 38, approximately 4-fold less than BI 689648. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
After oral administration in cyno monkeys, BI 689648 (5 mg/kg) exhibits a peak plasma concentration of ~500 nM. For BI 689648 (aldosterone EC 50 =2 nM), appreciable changes in 11-DOC are only noted at plasma concentrations >2000 nM or >1000-fold its aldosterone EC 50 while FAD286 shows a window of ~100-fold. BI 689648 exhibits minimal impact on 11-DC and only at very high plasma concentrations (~10 μM) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:IC50: 310 nM (CYP11B1), 2.1 nM (CYP11B2)
| Isomeric SMILES | COCC1=CC(=CN=C1)C2=CC3=C(N=C2)N(CCC3)C(=O)N |
|---|---|
| PubChem CID | 86305663 |
| MeSH Entry Terms | 6-(5-methoxymethylpyridin-3-yl)-3,4-dihydro-2H-(1,8)naphthyridine-1-carboxylic acid amide;BI 689648 |
| Molecular Weight | 298.34 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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