Bikinin - 10mM in DMSO , CAS No.188011-69-0

CAS: 188011-69-0 Cat. No.: B422294 Formula: C₉H₉BrN₂O₃ Peso molecolare: 273.09 Numero EC: 694-754-3

GRADE & PURITY 10mM in DMSO

Synonyms

STK005425 | BCP15563 | Bikinin | Bikinin; Abrasin | Abrasin | HMS2304N16 | DB08578 | IFLab1_000935 | HY-12524 | SX2 | 4-((5-Bromopyridin-2-yl)amino)-4-oxobutanoic acid | S7722 | F0216-0029 | 3-[(5-bromopyridin-2-yl)carbamoyl]propanoic acid | 4-[(5-bromopy

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Bikinin is an ATP-competitive Arabidopsis GSK-3 inhibitor, and acts as a strong activator of brassinosteroid (BR) signaling.

Specifications

Sinonimi

STK005425 | BCP15563 | Bikinin | Bikinin; Abrasin | Abrasin | HMS2304N16 | DB08578 | IFLab1_000935 | HY-12524 | SX2 | 4-((5-Bromopyridin-2-yl)amino)-4-oxobutanoic acid | S7722 | F0216-0029 | 3-[(5-bromopyridin-2-yl)carbamoyl]propanoic acid | 4-[(5-bromopy

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Cell-permeable, ATP-competitive GSK-3 inhibitor. Highly selective for 7 Arabidopsis. Strongly activates brassinosteroid signalling .

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

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Tipo di azione

INHIBITOR

Nomi e identificatori

• Pubchem Sid: 528763576
• Sorrisi canonici: C1=CC(=NC=C1Br)NC(=O)CCC(=O)O
• IUPAC Name: 4-[(5-bromopyridin-2-yl)amino]-4-oxobutanoic acid
• InChIKey: XFYYQDHEDOXWGA-UHFFFAOYSA-N
• INCHI: 1S/C9H9BrN2O3/c10-6-1-2-7(11-5-6)12-8(13)3-4-9(14)15/h1-2,5H,3-4H2,(H,14,15)(H,11,12,13)
• Isomeri SMILES: C1=CC(=NC=C1Br)NC(=O)CCC(=O)O
• WGK Germania: 3
• Peso molecolare: 273.09
• Reaxy-Rn: 8144877
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8144877&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Classe Organonitrogen compounds
      • Subclass N-arylamides

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Classe: Organonitrogen compounds
• Subclass: N-arylamides
• Intermediate Tree Nodes: Not available
• Direct Parent: N-arylamides
• Alternative Parents: Pyridines and derivatives Imidolactams Fatty amides Aryl bromides Heteroaromatic compounds Secondary carboxylic acid amides Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organopnictogen compounds Organobromides Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: N-arylamide - Aryl bromide - Aryl halide - Fatty amide - Pyridine - Fatty acyl - Imidolactam - Heteroaromatic compound - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Azacycle - Organoheterocyclic compound - Organopnictogen compound - Hydrocarbon derivative - Organic oxygen compound - Organohalogen compound - Organobromide - Organooxygen compound - Carbonyl group - Organic oxide - Aromatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as n-arylamides. These are organic compounds that contain a carboxamide group that is N-linked to a aryl group. They have the generic structure RC(=O)N(R')H, R = organyl group and R'= aryl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

Discover Target: TSHR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

Discover Target: TP53

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)

Discover Target: GNAS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Obiettivi associati (non umani)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Proprietà chimiche e fisiche

• Sensibilità: Heat Sensitive
• Punto di fusione (°C): 144 °C
• Peso molecolare: 273.080 g/mol
• XLogP3: 0.500
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 271.98 Da
• Monoisotopic Mass: 271.98 Da
• Topological Polar Surface Area: 79.300 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 248.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1