Blasticidin-S - HCl - ≥96% , CAS No.3513-03-9

CAS: 3513-03-9 Cat. No.: B139600 Formula: C₁₇H₂₆N₈O₅·HCl Peso molecolare: 458.9 Numero EC: 609-067-6 PubChem CID: 75412545

QUALITÀ & PUREZZA ≥96%

Synonyms

(2S,3S,6R)-3-[[(3S)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid;hydrochloride | blasticidin S HCl | (2S,3S,6R)-6-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-[(3S)-3-amino-5-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Blasticidin S Hydrochloride belongs to a group of cytosine amino nucleoside antibiotics. The compound Blasticidin S has a wide spectrum of antimicrobial activity and acts on prokaryotic and eukaryotic organisms by inhibiting protein synthesis.
Blasticidin-S is a commonly used tool in genetic engineering. Blasticidin-S inhibits protein synthesis in both prokaryotic and eukaryotic cells. It is common method to include a gene for Blasticidin S resistance into the plasmid being inserted into the target cells, and then to apply Blasticidin S to the culture to select these cells that have acquired that immunity. The Blasticidin S gene resistance gene (BSR), found in Bacillus cereus K55-S1, has been used in multiple studies for its use as a selective compound. Another antibiotic that belongs to the family of nucleosides is puromycin

Product description

Blasticidin S has been used to: Study fungicidal properties, and to prevent rice blast; Used as a selection agent for transformed cells containing the resistance genes bls, bsr, or bsd. Blasticidin S has been used to select HEK293-T cells and HEK-D5 cells with TLR-2 constructs; Used to study protein synthesis at the level of peptide bond formation.

Specifiche

Sinonimi

(2S,3S,6R)-3-[[(3S)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid;hydrochloride | blasticidin S HCl | (2S,3S,6R)-6-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-[(3S)-3-amino-5-

Specifiche e purezza

≥96%

Meccanismi biochimici e fisiologici

Blasticidin S Hydrochloride, like puromycin, belongs to a group of cytosine amino nucleoside antibiotics. The compound blasticidin S has a wide spectrum of antimicrobial activity and acts on prokaryotic and eukaryotic organisms by inhibiting protein synth

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic -refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purezza

≥96%

Nomi e identificatori

Pubchem Sid

528773074

Sorrisi canonici

CN(CCC(CC(=O)NC1C=CC(OC1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl

IUPAC Name

(2S,3S,6R)-3-[[(3S)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid;hydrochloride

InChIKey

YQXYQOXRCNEATG-NMQKUDMSSA-N

INCHI

1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10-,13+,14-;/m0./s1

Isomeri SMILES

CN(CC[C@@H](CC(=O)N[C@H]1C=C[C@@H](O[C@@H]1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl

WGK Germania

2

PubChem CID

75412545

Peso molecolare

458.9

Proprietà chimiche e fisiche

• Solubilità: soluble in water, Acetic acid;Slightly soluble in acidified methanol.
• Sensibilità: Moisture sensitive
• Indice di rifrazione: 1.71
• Punto di ebollizione (°C): 772.1 °C at 760 mmHg
• Peso molecolare: 458.900 g/mol
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 458.179 Da
• Monoisotopic Mass: 458.179 Da
• Topological Polar Surface Area: 213.000 Ų
• Heavy Atom Count: 31
• Formal Charge: 0
• Complexity: 795.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3