BLT-1 - ≥98% , CAS No.321673-30-7

CAS: 321673-30-7 Cat. No.: B412587 Formula: C₁₂H₂₃N₃S Peso molecolare: 241.4

QUALITÀ & PUREZZA ≥98%

Synonyms

33M20 | Probes2_000409 | DTXSID80430563 | Probes1_000008 | Probes1_000093 | Probes2_000390 | BLT-1 | E74752 | EN300-68381 | (2Z)-2-(2-hexylcyclopentylidene)hydrazinecarbothioamide | EX-A4880 | [(2-hexylcyclopentylidene)amino]thiourea | Z275117012 | SCHEMB

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

BLT-1 (Block lipid transport-1) has been used as an inhibitor of the SR-BI (scavenger receptor, class B, type I) mediated lipid transfer to determine if miR-223-3p export from polymorphonuclear neutrophils (PMNs) to high-density lipoproteins (HDLs) is dependent on SR-BI-mediated lipid flux. It has also been used as a SR-BI inhibitor to study the effect of HDL on osteocalcin (OCN) expression in monocyte cell lines through SR-B1. BLT-1 may be used to study cell signaling pathways that have role in cholesterol influx and efflux.

Specifiche

Sinonimi

33M20 | Probes2_000409 | DTXSID80430563 | Probes1_000008 | Probes1_000093 | Probes2_000390 | BLT-1 | E74752 | EN300-68381 | (2Z)-2-(2-hexylcyclopentylidene)hydrazinecarbothioamide | EX-A4880 | [(2-hexylcyclopentylidene)amino]thiourea | Z275117012 | SCHEMB

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

BLT-1 is an inhibitor of HDL receptor SR-BI. BLT-1 is primarily used for phosphorylation and dephosphorylation applications.Block lipid transport-1 (BLT-1) is a specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer.

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Purezza

≥98%

Nomi e identificatori

Pubchem Sid

528763451

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/528763451

Sorrisi canonici

CCCCCCC1CCCC1=NNC(=S)N

IUPAC Name

[(E)-(2-hexylcyclopentylidene)amino]thiourea

InChIKey

OWGUSBISUVLUJF-SDNWHVSQSA-N

INCHI

1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)/b14-11+

Isomeri SMILES

CCCCCCC\1CCC/C1=N\NC(=S)N

WGK Germania

3

Peso molecolare

241.4

Reaxy-Rn

11250336

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11250336&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Classe Organonitrogen compounds
      • Subclass Hydrazines and derivatives
        • Level5 Thiosemicarbazides
          • Level6 Thiosemicarbazones

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Classe: Organonitrogen compounds
• Subclass: Hydrazines and derivatives
• Intermediate Tree Nodes: Thiosemicarbazides
• Direct Parent: Thiosemicarbazones
• Alternative Parents: Organosulfur compounds Hydrocarbon derivatives
• Molecular Framework: Aliphatic homomonocyclic compounds
• Substituents: Thiosemicarbazone - Hydrocarbon derivative - Organosulfur compound - Aliphatic homomonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as thiosemicarbazones. These are compounds containing the thiosemicarbazone functional group obtained by replacing the carbonyl group by a thiocarbonyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: DMSO: ≥13 mg/mL
• Peso molecolare: 241.400 g/mol
• XLogP3: 3.300
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 241.161 Da
• Monoisotopic Mass: 241.161 Da
• Topological Polar Surface Area: 82.500 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 251.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1