BMS-986242 - 10mM in DMSO , CAS No.1923844-48-7

CAS: 1923844-48-7 Cat. No.: B655039 Molecular Weight: 410.91 PubChem CID: 121318866

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 ( IDO1 ) inhibitor. BMS-986242 can be used for the research of cancer

In Vitro

BMS-986242 is more prone to oxidative metabolism and less susceptible to glucuronidation. BMS-986242 shows IC 50 >25 μM for all targets except nAChR a1 (IC 50 =12.3 μM) and nAChR a7 (IC 50 >6 μM with ∼20 % max inhibition). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) exhibits dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: nu/nu Mouse Dosage: 3~30 mg/kg Administration: P.o. Result: Exhibited dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses.

IC50& Target:IDO1

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

BMS-986242 is an orally active, potent and selective indoleamine-2, 3-dioxygenase 1 ( IDO1 ) inhibitor. BMS-986242 can be used for the research of cancer.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C[C@H](C1CCC(CC1)C2=C3C=C(C=CC3=NC=C2)F)NC(=O)C4=CC=C(C=C4)Cl
• PubChem CID: 121318866
• Molecular Weight: 410.91