BOC-D-FMK - 10mM in DMSO , CAS No.634911-80-1

CAS: 634911-80-1 Cat. No.: B656505 Formula: C₁₁H₁₈FNO₅ Peso molecolare: 263.26

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC 50 of 39 µM.

In Vitro

Apoptosis is a pathway of cell death orchestrated by a family of proteases called caspases. Boc-D-fmk inhibits TNFα-stimulated reactive oxygen species (ROS) generation. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC 50 of 39 µM. BocD-fmk at 50 µM prevents genistein-induced apoptosis of p815 cells. Confocal microscopy shows that the release of mitochondrial apoptotic factors is inhibited by BocD-fmk. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after endotoxin challenge. A single injection of Boc-D-FMK results in longterm protection of MNs against root avulsion-induced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Caspase

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC 50 of 39 µM.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

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Tipo di azione

INHIBITOR

Nomi e identificatori

• Isomeri SMILES: CC(C)(C)OC(=O)NC(CC(=O)OC)C(=O)CF
• CAS alternativo: 187389-53-3
• Termini MeSH: Boc-D-FMK
• Peso molecolare: 263.26
• Reaxy-Rn: 32252135
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32252135&ln=