Bocidelpar - Moligand™,≥98% , CAS No.2095128-20-2

CAS: 2095128-20-2 Cat. No.: B648929 Formula: C₂₅H₂₇F₃N₂O₃ Peso molecolare: 460.49 PubChem CID: 126752383

QUALITÀ & PUREZZA Moligand™, ≥98%

Synonyms

(R)-3-Methyl-6-(2-((5-methyl-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid | ASP0367 | MA-0211 | SP-0367

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Bocidelpar is a selective PPARδ modulator. Bocidelpar activates the PPARδ downstream signaling pathway, upregulates the expression of target genes such as ABCA1 and ACAA2. Bocidelpar then promotes fatty acid oxidation (FAO) and mitochondrial biogenesis, and improves mitochondrial dysfunction. Bocidelpar can improve mitochondrial biogenesis and function in muscle cells. Bocidelpar is mainly used in the study of mitochondrial dysfunction diseases such as primary mitochondrial myopathy (PMM) and Duchenne muscular dystrophy (DMD).

Specifiche

Sinonimi

(R)-3-Methyl-6-(2-((5-methyl-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid | ASP0367 | MA-0211 | SP-0367

Specifiche e purezza

Moligand™,≥98%

Meccanismi biochimici e fisiologici

Bocidelpar is a modulator of peroxisome proliferator-activated receptor delta ( PPAR-δ ). Bocidelpar improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy (DMD) muscle cells (extracted from patent WO2017062468A1, compound 2b).

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

MODULATOR

Purezza

≥98%

Nomi e identificatori

Isomeri SMILES

CC1=CN=C(N1CC2=CC=CC=C2OCCC[C@@H](C)CC(=O)O)C3=CC=C(C=C3)C(F)(F)F

PubChem CID

126752383

Peso molecolare

460.49

Proprietà chimiche e fisiche

• Solubilità: DMSO : 250 mg/mL (542.90 mM; Need ultrasonic)
• Peso molecolare: 460.500 g/mol
• XLogP3: 5.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 10
• Exact Mass: 460.197 Da
• Monoisotopic Mass: 460.197 Da
• Topological Polar Surface Area: 64.400 Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 610.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1