Brefeldin A - Moligand™, ≥98%(HPLC), from Penicillium brefeldianum , CAS No.20350-15-6

Name: Brefeldin A - Moligand™, ≥98%(HPLC), from Penicillium brefeldianum , CAS No.20350-15-6
Brand: Aladdin Scientific
SKU: B102375
Availability: InStock

CAS: 20350-15-6 Cat. No.: B102375 Formula: C₁₆H₂₄O₄ Peso molecolare: 280.36 Beilstein Registry Number: 25191 Numero EC: 606-528-3

7 Citations COA

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Brefeldin A - Moligand™,≥98%(HPLC),from Penicillium brefeldianum CAS No(20350-15-6) by Aladdin Scientific

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QUALITÀ & PUREZZA Moligand™ ? ≥98%(HPLC) from Penicillium brefeldianum

Synonyms

BFA | BFA | MLS002701937 | s7046 | Decumbin | 4H-Cyclopent(f)oxacyclotridecin-4-one, 1,6,7,8,9,11a-beta,12,13,14,14a-alpha-decahydro-1-beta-13-alpha-dihydroxy-6-beta-methyl- | brefeldin A | SMR000653527 | AM84700 | cid_5287620 | SMR000768725 | NSC-89671 |

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Scheda delle specifiche

Panoramica Specifiche Proprietà del prodotto Nomi e identificatori Documentazione Dati avanzati Taxonomic Classification Struttura 3D Obiettivi associati (umani) Obiettivi associati (non umani) Meccanismi d'azione Certificati (CoA, COO, BSE/TSE e tabella di analisi) Proprietà chimiche e fisiche Domande frequenti e articoli Citations of This Product Calcolatori di soluzioni Recensioni

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Perché questa qualità

Moligand™, ≥98%(HPLC), from Penicillium brefeldianum Moligand™ per flussi di lavoro cromatografici e analitici sensibili che richiedono un'interferenza minima della linea di base.

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Stoccaggio e spedizione

Store at -20°C,Argon charged Spedizione Ice chest + Ice pads. Consultare il COA specifico del lotto per le specifiche esatte.

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Documenti di qualità

SDS, COA, scheda tecnica e scheda delle specifiche disponibili per il download. COA specifico del lotto accessibile tramite ricerca per numero di lotto.

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Prova documentale

Citato in 7 pubblicazioni peer-reviewed su cromatografia, sintesi organica e reazioni di accoppiamento incrociato.

Panoramica

Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Also available as a 25 mM solution in DMSO. Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange.
A fungal metabolite exhibiting a wide range of antibiotic activities and activator of caspase-3. Inhibitor of protein translocation from endoplasmic reticulum (ER) to the Golgi apparatus. Inhibitor of intracellular protein transport and protein secretion.

Specifiche

Sinonimi

Specifiche e purezza

Moligand™, ≥98%(HPLC), from Penicillium brefeldianum

Meccanismi biochimici e fisiologici

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.Reversible inhibitor of protei

Condizioni di conservazione di stoccaggio

Store at -20°C,Argon charged

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purezza

≥98%(HPLC)

Proprietà del prodotto

Gamme di eccitazione ed emissione

215 nm (EtOH)

Nomi e identificatori

Pubchem Sid

528771643

Sorrisi canonici

CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O

IUPAC Name

(1R,2R,3E,7S,11E,13S,15S)-2,15-dihydroxy-7-methyl-6-oxabicyclo[11.3.0]hexadeca-3,11-dien-5-one

InChIKey

KQNZDYYTLMIZCT-KQPMLPITSA-N

INCHI

1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1

Isomeri SMILES

C[C@H]1CCC/C=C/[C@@H]2C[C@@H](C[C@H]2[C@@H](/C=C/C(=O)O1)O)O

WGK Germania

RTECS

GY8410000

Numero UN

2811

Peso molecolare

280.36

Beilstein

25191

Reaxy-Rn

30543489

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30543489&ln=

Documentazione

📋 Scheda di dati di sicurezza (SDS)

Documento completo su pericoli, manipolazione, stoccaggio e conformità normativa.

<<<<<<< HEAD Scarica SDS → ======= Scarica SDS → >>>>>>> release248-p3

✅ Certificato di analisi (COA)

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Riepilogo di riferimento rapido delle specifiche e applicazioni del prodotto.

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Dati avanzati

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Classe Macrolides and analogues

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Classe	Macrolides and analogues
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Macrolides and analogues
Alternative Parents	Enoate esters Secondary alcohols Lactones Cyclic alcohols and derivatives Oxacyclic compounds Monocarboxylic acids and derivatives Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aliphatic heteropolycyclic compounds
Substituents	Macrolide - Cyclic alcohol - Alpha,beta-unsaturated carboxylic ester - Enoate ester - Carboxylic acid ester - Lactone - Secondary alcohol - Carboxylic acid derivative - Oxacycle - Monocarboxylic acid or derivatives - Organoheterocyclic compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Carbonyl group - Organooxygen compound - Alcohol - Aliphatic heteropolycyclic compound
Descrizione	This compound belongs to the class of organic compounds known as macrolides and analogues. These are organic compounds containing a lactone ring of at least twelve members.
External Descriptors	macrolide antibiotic
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Struttura 3D

Obiettivi associati (umani)

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)

Discover Target: THRB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRNP Tchem Prion protein (409 Activities)

Discover Target: PRNP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAPK3 Tchem MAP kinase ERK1 (4725 Activities)

Discover Target: MAPK3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AKT1 Tchem Serine/threonine-protein kinase AKT (9192 Activities)

Discover Target: AKT1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

Lot Number	Certificate Type	Data	Oggetto
C2627286	Certificate of Analysis	Mar 10, 2026	B102375
C2627287	Certificate of Analysis	Mar 10, 2026	B102375
C2627288	Certificate of Analysis	Mar 10, 2026	B102375
C2627290	Certificate of Analysis	Mar 10, 2026	B102375
J2326028	Certificate of Analysis	Oct 13, 2023	B102375
J2326029	Certificate of Analysis	Oct 13, 2023	B102375
J2326030	Certificate of Analysis	Oct 13, 2023	B102375
J2326031	Certificate of Analysis	Oct 13, 2023	B102375
B2224424	Certificate of Analysis	Jan 17, 2022	B102375
B2224433	Certificate of Analysis	Jan 17, 2022	B102375
B2224436	Certificate of Analysis	Jan 17, 2022	B102375
B2224440	Certificate of Analysis	Jan 17, 2022	B102375
H2105084	Certificate of Analysis	Mar 20, 2021	B102375

Solubilità	Soluble in Methanol, Ethanol, Dichloromethane, DMSO, acetone or ethyl acetate
Sensibilità	light sensitive；Moisture sensitive；Heat sensitive
Rotazione specifica [α]	93° (C=2,MeOH)
Punto di fusione (°C)	201-205°C
Peso molecolare	280.360 g/mol
XLogP3	2.000
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	280.167 Da
Monoisotopic Mass	280.167 Da
Topological Polar Surface Area	66.800 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	388.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	2
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	2
Covalently-Bonded Unit Count	1

Brefeldin A - Moligand™, ≥98%(HPLC), from Penicillium brefeldianum , CAS No.20350-15-6

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