10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
🌡
Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
📋
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
📚
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Panoramica
BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases ( BSH s) with IC 50 s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively.
In Vitro
BSH-IN-1 (Compound 7) also inhibits BSH activity in growing cultures of Gram-negative ( B. theta VPI-5482, Bacteroides fragilis ATCC 25285, and Bacteroides vulgatus ATCC 8482) and Gram-positive ( Lactobacillus plantarum WCFS1, C. perfringens ATCC 13124, and Bifidobacterium adolescentis L2-32) bacteria. BSH-IN-1 (Compound 7) also is a potent BSH inhibitor in growing bacterial cultures with IC 50 s of 237 nM and 1070 nM for B. adolescentis (Gram positive) and B. theta (Gram negative), respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
BSH-IN-1 (Compound 7; 10 mg/kg; a single dose; gavage) inhibits BSH activity in C57BL/6 mice and can be gut-restricted . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 mice Dosage: 10 mg/kg Administration: Single gavage Result: Inhibited gut bacterial BSH activity and modulated the bile acid pool in vivo while not significantly affected the gut bacterial community.
Specifications
Specifiche e purezza
10mM in DMSO
Meccanismi biochimici e fisiologici
BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases ( BSH s) with IC 50 s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively.
Condizioni di conservazione di stoccaggio
Store at -80°C
Spedito in
Dry ice packs + Cold packs
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
Tipo di azione
INHIBITOR
Nomi e identificatori
PubChem CID
145713829
Peso molecolare
408.59
Documentazione
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
We use cookies to ensure the website functions properly and, where permitted, to improve your experience. You can manage your preferences at any time in Settings. Learn more in our Cookie Policy.
Shall we send you a message when we have discounts available?
Remind me later
Thank you! Please check your email inbox to confirm.
Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
