BTK inhibitor 18 , CAS No.B659062

CAS: B659062 Cat. No.: B659062 Formula: C₂₉H₂₅N₅O₄S₂ Peso molecolare: 571.67

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Panoramica

BTK inhibitor 18 is a potent, selective,orally active and covalent Btk inhibitor with a IC 50 of 142 nM. BTK inhibitor 18 has anti-inflammatory activities.

IC50& Target:IC50: 142 nM (Btk)

In Vitro:BTK inhibitor 18 (Compound 27) irreversibly inhibits BTK by targeting a noncatalytic cysteine residue (Cys481) for covalent bond formation. BTK inhibitor 18 (Compound 27) inhibits anti-IgM-induced activation of B cells in human whole blood with an IC

In Vivo:BTK inhibitor 18 (Compound 27; 1-30mg/kg; oral administration; once a day; for 7 days) treatment shows dose-dependent efficacy at reducing joint inflammation in a rat collagen-induced arthritis model. The IV and PO pharmacokinetics of BTK inhibitor

Biological Activity:BTK inhibitor 18 is a potent, selective,orally active and covalent Btk inhibitor with a IC 50 of 142 nM. BTK inhibitor 18 has anti-inflammatory activities.

Specifiche

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

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Tipo di azione

INHIBITOR

Nomi e identificatori

Peso molecolare

571.67