Bumetanide - Moligand™, 10mM in DMSO , Sodium-(potassium)-chloride cotransporter 2 inhibitor, CAS No.28395-03-1, Sodium-(potassium)-chloride cotransporter 2 inhibitor

CAS: 28395-03-1 Cat. No.: B407775 Formula: C₁₇H₂₀N₂O₅S Peso molecolare: 364.42 Numero EC: 249-004-6

QUALITÀ & PUREZZA Moligand™, 10mM in DMSO

Synonyms

Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Bumetanide Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respe
In vitro

In vivo

Cell Data

cell lines：MV-4-11, MM.1S, and K562 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifiche

Sinonimi

Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

AGONIST, INHIBITOR

Meccanismo d'azione

Sodium-(potassium)-chloride cotransporter 2 inhibitor

Proprietà del prodotto

ALogP

2.8

Nomi e identificatori

Isomeri SMILES

CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2

WGK Germania

3

RTECS

DG4910000

Peso molecolare

364.42

Reaxy-Rn

2185351

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2185351&ln=

Obiettivi associati (umani)

SLC12A1 Tclin Solute carrier family 12 member 1 (1 Activities)

Discover Target: SLC12A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC12A2 Tclin Solute carrier family 12 member 2 (1 Activities)

Discover Target: SLC12A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Domande frequenti

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 28395-03-1, the molecular formula is C17H20N2O5S, and the molecular weight is 364.42 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.