BV-6 TFA salt - Moligand™, ≥98% , CAS No.1001600-56-1(freebase)

CAS: 1001600-56-1(freebase) Cat. No.: B413788 Formula: C₇₀H₉₆N₁₀O₈.xCF₃COOH Peso molecolare: 1205.57（free）

GRADE & PURITY Moligand™, ≥98%

Synonyms

N,N'-(hexane-1,6-diyl)bis(1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninamide):trifluoroacetic acid(1:x)

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Information

BV-6 is a SMAC mimetic, dualcIAPandXIAPinhibitor.

Targets

cIAP ; XIAP

In vitro

BV6 inhibits the cell viability of HCC193 NSCLC cells with IC50 of 7.2 μM, induces apoptosis in both HCC193 and H460 cell lines, and also significantly enhances the radiosensitivity of these cell lines through activation of cleaved caspase-8 and cleaved caspase-9, respectively. In immature dendritic cells, BV-6 treatment results in moderate activation of the classical NF-kB pathway. Furthermore, BV-6 increases CIK cell-mediated lysis of hematological (H9, THP-1, and Tanoue) and solid malignancies (RH1, RH30, and TE671). BV-6 also enhances apoptosis of peripheral blood mononuclear cells and most notably has an inhibitory effect on immune cells limiting their cytotoxic potential.

Cell Research(from reference)

Cell lines：HCC193 and H460 cells 

Concentrations：~30 μM 

Incubation Time：~48 hours 

Specifications

Sinonimi

N,N'-(hexane-1,6-diyl)bis(1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninamide):trifluoroacetic acid(1:x)

Specifiche e purezza

Moligand™, ≥98%

Meccanismi biochimici e fisiologici

BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Purezza

≥98%

Nomi e identificatori

• Pubchem Sid: 488200364
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488200364
• Sorrisi canonici: CNC(C)C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC(C(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)NCCCCCCNC(=O)C(NC(=O)C5CCCN5C(=O)C(NC(=O)C(C)NC)C6CCCCC6)C(C7=CC=CC=C7)C8=CC=CC=C8
• Peso molecolare: 1205.57（free）

Obiettivi associati (umani)

XIAP Tchem E3 ubiquitin-protein ligase XIAP (1 Activities)

Discover Target: XIAP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 100 mg/mL (82.94 mM); Water: 100 mg/mL (82.94 mM); Ethanol: 100 mg/mL warmed with 50ºC Water: bath (82.94 mM)