Carbimazole - 10mM in DMSO , Thyroid peroxidase inhibitor, CAS No.22232-54-8, Thyroid peroxidase inhibitor

CAS: 22232-54-8 Cat. No.: C408083 Formula: C₇H₁₀N₂O₂S Peso molecolare: 186.23 Numero EC: 244-854-4

GRADE & PURITY 10mM in DMSO

Synonyms

1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Carbimazole is an imidazole antithyroid agent.
In vitro

Carbimazole is an effective thyroid hormone inhibitor under a class of drugs known as pro-drugs. It is considered a pro-drug because it converts to methimazole after being absorbed by the body, generating an antithyroid action that works against hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (inflammation of the thyroid gland). Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine).

In vivo

Cell Data

cell lines：Human breast cancer cells MDA-MB-231

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Carbimazole is an imidazole antithyroid agent.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Meccanismo d'azione

Thyroid peroxidase inhibitor

Proprietà del prodotto

• ALogP: 0.7

Nomi e identificatori

• Isomeri SMILES: CCOC(=O)N1C=CN(C1=S)C
• WGK Germania: 3
• Peso molecolare: 186.23
• Reaxy-Rn: 144339
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=144339&ln=

Proprietà chimiche e fisiche

• Punto di fusione (°C): 124 °C

Riferimenti

1. Nian Liu, Shuchao Zhang, Yiliang Liu, Xing Lu, Xiaozhen He.  (2025)  Potential Mechanisms Underlying Carbimazole-Induced Cardiotoxicity and Hepatotoxicity in Zebrafish.  JOURNAL OF APPLIED TOXICOLOGY,      [PMID:40784728] [10.1002/jat.4889]