Carboplatin - Moligand™, ≥99.95% metals basis , CAS No.41575-94-4

CAS: 41575-94-4 Cat. No.: C295384 Formula: C₆H₁₂N₂O₄Pt Peso molecolare: 371.25 Numero EC: 255-446-0

GRADE & PURITY Moligand™, ≥99.95% metals basis

Synonyms

AB01273939-01 | EN300-123065 | NSC758182 | NSC-758182 | STL451040 | Tox21_112586_1 | Carboplatinum | DTXCID201476080 | Amikacin impurity I, European Pharmacopoeia (EP) Reference Standard | Pharmakon1600-01502106 | SCHEMBL4964 | Lopac0_000230 | NSC201345 |

Storage

Store at 2-8°C,Protected from light

Shipped In

Wet ice

Panoramica

Carboplatin is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of carboplatin was inspired from the efficacy of its progenitor, Cisplatin (sc-200896), the first of this class of antineoplastic agents. The action of this group of platinum-based compounds is primarily attributed to DNA adduct formation, however, these molecules also bind other biological molecules, including enzymes, which might play a role in their mechanism of action.
An antitumor agent that binds to DNA leading to apoptosis

Product class
hAPIs, Metal based hAPIs

Chemical properties

Chemical formula

C6H12N2O4Pt

Empirical formula

[Pt(NH3)2(cbdc)]

Molecular weight

371.25

Metal

Pt

Theoretical metal content

53

Physical state

powder

Color
Metal purity

white

99.95

Specifications

Sinonimi

AB01273939-01 | EN300-123065 | NSC758182 | NSC-758182 | STL451040 | Tox21_112586_1 | Carboplatinum | DTXCID201476080 | Amikacin impurity I, European Pharmacopoeia (EP) Reference Standard | Pharmakon1600-01502106 | SCHEMBL4964 | Lopac0_000230 | NSC201345 |

Specifiche e purezza

Moligand™, ≥99.95% metals basis

Meccanismi biochimici e fisiologici

Carboplatin damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell de

Informazioni legali

Product of Umicore

Condizioni di conservazione di stoccaggio

Store at 2-8°C,Protected from light

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Purezza

≥99.95% metals basis

Nomi e identificatori

• Pubchem Sid: 504758672
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504758672
• Sorrisi canonici: C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
• IUPAC Name: azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+)
• InChIKey: VSRXQHXAPYXROS-UHFFFAOYSA-N
• INCHI: 1S/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H2;/q;2*-1;+2
• Isomeri SMILES: C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
• WGK Germania: 3
• RTECS: TP2300000
• CAS alternativo: 41575-94-4
• Numero NSC: 201345
• Termini MeSH: Blastocarb;Carboplat;Carboplatin;Carbosin;Carbotec;CBDCA;cis-Diammine(cyclobutanedicarboxylato)platinum II;Ercar;JM 8;JM-8;JM8;Nealorin;Neocarbo;NSC 241240;NSC-241240;NSC241240;Paraplatin;Paraplatine;Platinwas;Ribocarbo
• Peso molecolare: 371.25
• Reaxy-Rn: 25079300
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25079300&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Classe Carboxylic acids and derivatives
      • Subclass Dicarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Classe: Carboxylic acids and derivatives
• Subclass: Dicarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Dicarboxylic acids and derivatives
• Alternative Parents: Organic transition metal salts Carboxylic acids Organic oxides Organic nitrogen compounds Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic homomonocyclic compounds
• Substituents: Dicarboxylic acid or derivatives - Organic transition metal salt - Carboxylic acid - Organic nitrogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organic salt - Organooxygen compound - Carbonyl group - Aliphatic homomonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Proprietà chimiche e fisiche

• Solubilità: Soluble in water.
• Sensibilità: Light sensitive.
• Punto di fusione (°C): >275℃
• Peso molecolare: 371.250 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 0
• Exact Mass: 371.045 Da
• Monoisotopic Mass: 371.045 Da
• Topological Polar Surface Area: 76.600 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 177.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 4

XLogP3

Riferimenti

1. Wang Yaotai, Zhang Zhong, Ren Li, Luo Yong, Wang Qi, Zou Jianzhong.  (2023)  Dual mode imaging guided multi-functional bio-targeted oxygen production probes for tumor therapy.  JOURNAL OF NANOBIOTECHNOLOGY,  21  (1): (1-19).  [PMID:37120558] [10.1186/s12951-023-01901-7]

2. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye.  (2022)  Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme.  Bioactive Materials,      [PMID:36406255] [10.1016/j.bioactmat.2022.10.002]

3. Dong Luo, Wenzhi Chen, Wei Wang, Junlin Chen, Haopeng Xu, Jinyun Chen, Yan Wang.  (2021)  Low-intensity pulsed ultrasound alleviating myelosuppression of Sprague-Dawley rats after combined treating by paclitaxel and carboplatin.  Translational Cancer Research,      [PMID:35116446] [10.21037/tcr-20-3035]

4. Songhui Zhou, Ruicheng Wang, Hong Xiao.  (2020)  Adipocytes induce the resistance of ovarian cancer to carboplatin through ANGPTL4.  ONCOLOGY REPORTS,  44  (3): (927-938).  [PMID:32705217] [10.3892/or.2020.7647]

5. Tingyu Yu, Jiao Lin, Jin Zhao, Wei Huang, Lingwen Zeng, Zhiyuan Fang, Ning Xu.  (2017)  A simple in vitro tumor chemosensitivity assay based on cell penetrating peptide tagged luciferase.  PLoS One,  12  (11): (e0186184).  [PMID:29125836] [10.1371/journal.pone.0186184]

6. Juan Chen, Liuqing Huang, Xiaobing Yang, Yan Li, Tong Lin, Chentong Zhang, Jintang Li, Xuetao Luo.  (2024)  Development of receptor-targeted and pH-responsive zeolitic imidazole framework-90 nanoplatform for anti-ovarian cancer.  INORGANIC CHEMISTRY COMMUNICATIONS,      [PMID:] [10.1016/j.inoche.2024.112715]

7. Weibin Luo, Zhengyuan Yang, Shihua Gao, Bin Peng.  (2025)  Construction of Hollow Mesoporous Selenium Loaded With Carboplatin and Clacked With Bevacizumab-Functionalized Albumin Nanoparticles for HER2+ Lung Cancer.  BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY,      [PMID:40620098] [10.1002/bab.70007]

8. Kong Linghui, Hu Song, Zhao Ying, Huang Yan, Xiang Xiaobing, Yu Yang, Mao Xiaochun, Xie Kangjie, Zhu Xiaoyan, Xu Pingbo.  (2025)  Neutrophil extracellular traps induced by neoadjuvant chemotherapy of breast cancer promotes vascular endothelial damage.  BREAST CANCER RESEARCH,  27  (1): (1-19).  [PMID:40270028] [10.1186/s13058-025-02011-y]

9. Chen Biqing, Gao Jiayin, Sun Haizhu, Zhao Yinghan, Liu Yan, Lv Xinpeng, Qiu Xiaohong, Li Yang.  (2025)  Application of surface-enhanced Raman scattering combined with artificial intelligence for multiplex detection of chemotherapeutic agents used in solid tumors.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,      [PMID:41324706] [10.1007/s00216-025-06241-z]

10. Yong Wang, Jie Pi, Yuzi Zhao, Qingzhen Xie.  (2026)  Hyaluronic Acid-Modified Mesoporous Manganese Dioxide Combined with Carboplatin Synergistically Enhances Ovarian Cancer Therapy.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2025.107973]

11. Sai-Nan Qin, Yi-Xue Zhang, Yi-Jie Cao, Ting Wan, Yi-Yang Zhou, Shan-Shan Su, Yu-Qiong Guo, Jian-Jun Sun, Kalle Salminen.  (2026)  A self-assembled electrochemical aptasensor for one-step rapid detection of cisplatin in blood via aptamer conformational change.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2026.116962]

12. Ke Li, Zhengxiang Wang, Zaigang Zhou, Huan Ding, Sheng Wu, Yuan Li, Jianliang Shen.  (2026)  Mitochondria-Targeting Nanocuproptosis Breaks Immune Resistance.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202528750]

13. Song Hu, Linghui Kong, Mo Chen, Cheng Teng, Ying Zhao, Xiaohong Yuan, Shunv Cai, Xiaoyan Zhu, Pingbo Xu.  (2026)  Inhibition of the cGAS-STING pathway mitigates liver injury induced by docetaxel-carboplatin neoadjuvant chemotherapy via autophagy promotion.  ACTA BIOCHIMICA ET BIOPHYSICA SINICA,      [PMID:42212620] [10.3724/abbs.2026094]

14. Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min.  (2026)  Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer.  Advanced Science,      [PMID:42621703] [10.1002/advs.77249]

Domande frequenti

What does the trace-metals specification mean?

This product is specified at ≥99.95% on a trace-metals basis. That figure describes metallic impurity content rather than overall chemical assay, so it is the relevant specification for ICP-MS, semiconductor and battery applications. Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at 2–8 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 41575-94-4, the molecular formula is C6H12N2O4Pt, and the molecular weight is 371.25 g/mol. InChIKey VSRXQHXAPYXROS-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.