Cathepsin G Substrate, CAS No.70967-97-4

CAS: 70967-97-4 Cat. No.: C350144 Molecular Weight: 624.64

GRADE & PURITY ≥95%

Overview

Cathepsin G substrate (Suc-AAPF-pNA) is sensitive colorimetric substrate for chymotrypsin, human pancreatic elastase, human leukocyte cathepsin G, and peptidyl prolyl isomerase. It is also hydrolyzed by cathepsin G and chymase, and used for the quantitative determination of cathepsin G activity.

Specifications

Product Name

Cathepsin G Substrate, CAS No.70967-97-4

Synonyms

Suc-AAPF-pNA | N-Succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide | N-Succinyl-Ala-Ala-Pro-Phe-pNA

Specifications & Purity

≥95%

Sequence

Suc-Ala-Ala-Pro-Phe-pNA

Note

Soluble in N, N-dimethylformamide (DMF) at 25 mg/ml producing a clear, light yellow solution, also soluble in 5% dimethylformamide (v/v) in buffer and in distilled water at 4 mg/ml. A 20 mM solution in dimethyl sulfoxide (DMSO) has been prepared and stored

CAS

70967-97-4

Molecule Type

Peptide

Storage and Shipping

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Oligopeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Oligopeptides
• Alternative Parents: Phenylalanine and derivatives Proline and derivatives N-acyl-alpha amino acids and derivatives Alpha amino acid amides Alanine and derivatives Amphetamines and derivatives Anilides Nitrobenzenes Pyrrolidinecarboxamides Nitroaromatic compounds N-arylamides N-acylpyrrolidines N-acyl amines Tertiary carboxylic acid amides Secondary carboxylic acid amides Propargyl-type 1,3-dipolar organic compounds Organic oxoazanium compounds Azacyclic compounds Carboxylic acids Monocarboxylic acids and derivatives Carbonyl compounds Organic zwitterions Hydrocarbon derivatives Organic salts Organic oxides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Alpha-oligopeptide - Phenylalanine or derivatives - Proline or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Alanine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Amphetamine or derivatives - Anilide - Nitrobenzene - Nitroaromatic compound - N-acylpyrrolidine - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - N-arylamide - Monocyclic benzene moiety - Fatty amide - N-acyl-amine - Fatty acyl - Benzenoid - Tertiary carboxylic acid amide - Pyrrolidine - Secondary carboxylic acid amide - Carboxamide group - C-nitro compound - Organic nitro compound - Propargyl-type 1,3-dipolar organic compound - Organoheterocyclic compound - Allyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organic oxoazanium - Azacycle - Carboxylic acid - Monocarboxylic acid or derivatives - Organic salt - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Carbonyl group - Organic nitrogen compound - Organonitrogen compound - Organic zwitterion - Organooxygen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

CTRC Tchem Chymotrypsin C (381 Activities)

Discover Target: CTRC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FKBP4 Tchem FK506 binding protein 4 (257 Activities)

Discover Target: FKBP4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

References

1. Dandan Feng, Zhu Zhu, Shangpeng Wang, Yangcan Gao, Yingwen Li, Yuying Sun, Jiquan Zhang.  (2025)  A type I crustin with an inhibitory effect on proteases and strong binding capacity to chitin from Neocaridina denticulata sinensis.  Comparative Immunology Reports,      [PMID:] [10.1016/j.cirep.2025.200226]