Cefoperazone sodium - 10mM in DMSO , CAS No.62893-20-3

CAS: 62893-20-3 Cat. No.: C425189 Formula: C₂₅H₂₆N₉NaO₈S₂ Peso molecolare: 667.65 Beilstein Registry Number: 4902135 Numero EC: 263-751-5

GRADE & PURITY 10mM in DMSO

Synonyms

CEFOPERAZONE SODIUM (EP MONOGRAPH) | CHEBI:3494 | UNII-5FQG9774WD | 2-([2-(Acetyloxy)benzoyl]oxy)benzoic acid # | M0448 | Sodium (6R,7R)-7-((R)-2-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-2-(p-hydroxyphenyl)acetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Cefoperazone sodium salt is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM
An inhibitor of inactivation of α-antitrypsin

Specifications

Sinonimi

CEFOPERAZONE SODIUM (EP MONOGRAPH) | CHEBI:3494 | UNII-5FQG9774WD | 2-([2-(Acetyloxy)benzoyl]oxy)benzoic acid # | M0448 | Sodium (6R,7R)-7-((R)-2-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-2-(p-hydroxyphenyl)acetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Cefoperazone Sodium is an antimicrobial agent useful for prevention of postoperative infection. Inhibitor of inactivation of α(1)-antitrypsin.Broad-spectrum cephalosporin resistant to beta-lactamase. Inhibitor of inactivation of α 1 -antitrypsin. Shows an

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

• Pubchem Sid: 528771276
• Sorrisi canonici: CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=C(C=C2)O)C(=O)NC3C4N(C3=O)C(=C(CS4)CSC5=NN=NN5C)C(=O)[O-].[Na+]
• IUPAC Name: sodium;(6R,7R)-7-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• InChIKey: NCFTXMQPRQZFMZ-WERGMSTESA-M
• INCHI: 1S/C25H27N9O8S2.Na/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2;/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41);/q;+1/p-1/t15-,16-,22-;/m1./s1
• Isomeri SMILES: CCN1CCN(C(=O)C1=O)C(=O)N[C@H](C2=CC=C(C=C2)O)C(=O)N[C@H]3[C@@H]4N(C3=O)C(=C(CS4)CSC5=NN=NN5C)C(=O)[O-].[Na+]
• WGK Germania: 2
• Peso molecolare: 667.65
• Beilstein: 4902135
• Reaxy-Rn: 53833170
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=53833170&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Classe Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 N-acyl-alpha amino acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Classe: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: N-acyl-alpha amino acids and derivatives
• Alternative Parents: Cephems Dioxopiperazines Alkylarylthioethers Phenoxides N-alkylpiperazines N-acyl ureas 1,3-thiazines Tetrazoles Tertiary carboxylic acid amides Heteroaromatic compounds Azetidines Isoureas Thiohemiaminal derivatives Sulfenyl compounds Azacyclic compounds Propargyl-type 1,3-dipolar organic compounds Carboximidamides Carboxylic acids Monocarboxylic acids and derivatives Dialkylthioethers Carbonyl compounds Organic zwitterions Organic sodium salts Hydrocarbon derivatives Organic oxides Organopnictogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: N-acyl-alpha amino acid or derivatives - Cephem - Aryl thioether - Dioxopiperazine - N-acyl urea - Phenoxide - Ureide - N-alkylpiperazine - Alkylarylthioether - Meta-thiazine - Monocyclic benzene moiety - 1,4-diazinane - Piperazine - Benzenoid - Beta-lactam - Azole - Tertiary carboxylic acid amide - Heteroaromatic compound - Tetrazole - Carboxamide group - Azetidine - Isourea - Lactam - Organoheterocyclic compound - Organic alkali metal salt - Dialkylthioether - Organic 1,3-dipolar compound - Carboximidic acid - Carboximidic acid derivative - Propargyl-type 1,3-dipolar organic compound - Carboxylic acid - Azacycle - Monocarboxylic acid or derivatives - Sulfenyl compound - Carboximidamide - Hemithioaminal - Thioether - Organic zwitterion - Organic sodium salt - Carbonyl group - Organopnictogen compound - Organic oxide - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Hydrocarbon derivative - Organic salt - Organic nitrogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as n-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid (or a derivative thereof) which bears an acyl group at its terminal nitrogen atom.
• External Descriptors: organic molecular entity

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

SLC22A6 Tclin Solute carrier family 22 member 6 (0 Activities)

Discover Target: SLC22A6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Obiettivi associati (non umani)

Pseudomonas aeruginosa (123386 Activities)

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Staphylococcus aureus (210822 Activities)

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Escherichia coli (133304 Activities)

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Listeria monocytogenes (2626 Activities)

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Trypanosoma cruzi (99888 Activities)

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Peso molecolare: 667.700 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 9
• Exact Mass: 667.124 Da
• Monoisotopic Mass: 667.124 Da
• Topological Polar Surface Area: 274.000 Ų
• Heavy Atom Count: 45
• Formal Charge: 0
• Complexity: 1250.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 3
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Riferimenti

1. Lijun Xie, Li Chen, Yongbo Wei, Nannan Chen, Tong Wu, Jingming Zhou, Hong Jiang, Feng Lin.  (2023)  Design, Synthesis and Biological Evaluation of Novel PEG-Rakicidin B1 Hybrid as Clostridium difficile (CD) Targeted Anti-Bacterial Agent.  MOLECULES,  28  (16): (6152).  [PMID:37630404] [10.3390/molecules28166152]

2. Yujia Chen, Wei Li, Li Wang, Bingmei Wang, Jian Suo.  (2024)  Novel inhibition of Staphylococcus aureus sortase A by plantamajoside: implications for controlling multidrug-resistant infections.  APPLIED AND ENVIRONMENTAL MICROBIOLOGY,      [PMID:39745463] [10.1128/aem.01804-24]

3. Chao Wang, Peijuan Chu, Tengfei He, Cheng Yi, Yue Yao, Lijia Liu, Chunhong Zhang.  (2025)  Natural product flavonoid of naringenin based thin-film composite polyester membranes preparation for antibiotic separation.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2025.134123]

4. Meng Liu, Peng Jiang, Binghui Ruan, Yunfei Cui, Junjie Zhang, Yuxiu Ye, Dongting Zhangsun, Sulan Luo, Yong Wu.  (2026)  Rational β-turn engineering of a disulfide-free β-hairpin-like antimicrobial peptide W2PG with enhanced stability, selectivity, and in vivo efficacy.  BIOORGANIC CHEMISTRY,      [PMID:41690116] [10.1016/j.bioorg.2026.109612]

5. Zhixiao Liu, Yuhang Zhao, Mingli Yin, Jiaxu Wan, Yangyang Huang, Guangqiu Lei, Kangfei Wang, Tianliang Zhu, Zhengyu Qiu, Xiaoran Zhang, Zhiming Mi.  (2026)  Tuning monomer spatial configuration for high-performance polyesteramide loose nanofiltration membranes toward antibiotic separation.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2026.125833]