Ceftizoxime sodium - 10mM in DMSO , Bacterial penicillin-binding protein inhibitor, CAS No.68401-82-1, Bacterial penicillin-binding protein inhibitor

CAS: 68401-82-1 Cat. No.: C425441 Formula: C₁₃H₁₂N₅NaO₅S₂ Peso molecolare: 405.39 Numero EC: 629-729-8

GRADE & PURITY 10mM in DMSO

Synonyms

SR-01000872666-1 | CEFTIZOXIME SODIUM [VANDF] | Epocelin (TN) | Monosodium Salt, Ceftizoxime | Cefizox | CEFTIZOXIME SODIUM [JAN] | SKF-88373 | 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)-(methoxyimino)acetyl)amino)-8-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Product description：

Ceftizoxime, a third-generation cephalosporin effective against Gram-negative and Gram-positive bacteria, binds penicillin-binding proteins (PBPs) to inhibit the bacterial cell wall synthesis. It rather resembles cefotaxime in its properties but is not subject to metabolism.

Application：

A broad spectrum antibiotic targeting a wide variety of Gram-positive and Gram-negative bacteria；

Specifications

Sinonimi

SR-01000872666-1 | CEFTIZOXIME SODIUM [VANDF] | Epocelin (TN) | Monosodium Salt, Ceftizoxime | Cefizox | CEFTIZOXIME SODIUM [JAN] | SKF-88373 | 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)-(methoxyimino)acetyl)amino)-8-

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Ceftizoxime is third generation cephalosporin effective against Gram-negative and Gram-positive bacteria. It binds penicillin-binding proteins (PBPs) and inhibits the bacterial cell wall synthesis.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Meccanismo d'azione

Bacterial penicillin-binding protein inhibitor

Nomi e identificatori

• Pubchem Sid: 528771280
• Sorrisi canonici: CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=CCS3)C(=O)[O-].[Na+]
• IUPAC Name: sodium;(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• InChIKey: ADLFUPFRVXCDMO-LIGXYSTNSA-M
• INCHI: 1S/C13H13N5O5S2.Na/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18;/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22);/q;+1/p-1/b17-7-;/t8-,11-;/m1./s1
• Isomeri SMILES: CO/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=CCS3)C(=O)[O-].[Na+]
• Peso molecolare: 405.39
• Reaxy-Rn: 46955995
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=46955995&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Classe Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 N-acyl-alpha amino acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Classe: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: N-acyl-alpha amino acids and derivatives
• Alternative Parents: Cephems 1,3-thiazines Thiazoles Tertiary carboxylic acid amides Heteroaromatic compounds Azetidines Isothioureas Thiohemiaminal derivatives Azacyclic compounds Propargyl-type 1,3-dipolar organic compounds Carboximidic acids Carboxylic acids Dialkylthioethers Monocarboxylic acids and derivatives Carbonyl compounds Organonitrogen compounds Hydrocarbon derivatives Organic zwitterions Organopnictogen compounds Organic oxides Organic sodium salts
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: N-acyl-alpha amino acid or derivatives - Cephem - Meta-thiazine - Azole - Beta-lactam - Heteroaromatic compound - Tertiary carboxylic acid amide - Thiazole - Azetidine - Carboxamide group - Isothiourea - Lactam - Carboximidic acid - Carboximidic acid derivative - Carboxylic acid - Azacycle - Organic alkali metal salt - Monocarboxylic acid or derivatives - Organoheterocyclic compound - Dialkylthioether - Thioether - Hemithioaminal - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organic sodium salt - Carbonyl group - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Organic salt - Hydrocarbon derivative - Organic oxygen compound - Organic zwitterion - Organopnictogen compound - Organic oxide - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as n-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid (or a derivative thereof) which bears an acyl group at its terminal nitrogen atom.
• External Descriptors: organic sodium salt

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (non umani)

Pseudomonas aeruginosa (123386 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Staphylococcus epidermidis (22802 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Enterococcus faecalis (29875 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Peso molecolare: 405.400 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 5
• Exact Mass: 405.018 Da
• Monoisotopic Mass: 405.018 Da
• Topological Polar Surface Area: 204.000 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 675.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 2

XLogP3

Riferimenti

1. Zhixiao Liu, Yuhang Zhao, Mingli Yin, Jiaxu Wan, Yangyang Huang, Guangqiu Lei, Kangfei Wang, Tianliang Zhu, Zhengyu Qiu, Xiaoran Zhang, Zhiming Mi.  (2026)  Tuning monomer spatial configuration for high-performance polyesteramide loose nanofiltration membranes toward antibiotic separation.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2026.125833]