Chloroquine Phosphate - ≥99% , Ferriprotoporphyrin IX inhibitor, CAS No.50-63-5, Ferriprotoporphyrin IX inhibitor

CAS: 50-63-5 Cat. No.: C129284 Formula: C₁₈H₂₆ClN₃·2H₃PO₄ Peso molecolare: 515.86 Beilstein Registry Number: 4223142 Numero EC: 200-055-2 PubChem CID: 64927

GRADE & PURITY ≥99%

Synonyms

1,4-Pentanediamine, N(sup 4)-(7-chloro-4-quinolinyl)-N(sup 1),N(sup 1)-diethyl-, phosphate (1:2) | CHLOROQUINE DIPHOSPHATE [MI] | NCGC00093746-02 | Aralen phosphate | CHLOROQUINE PHOSPHATE (MART.) | HMS2096N17 | UNII-6E17K3343P | CHLOROQUINE PHOSPHATE (US

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Chloroquine Phosphate is an antimalarial agent that has been discovered to have a distinct affinity for melanin. Used in the treatment of arthritis, malaria and Lupus. Chloroquine Phosphate is a substrate of MRP.
An antimalarial compound

Specifications

Sinonimi

1,4-Pentanediamine, N(sup 4)-(7-chloro-4-quinolinyl)-N(sup 1),N(sup 1)-diethyl-, phosphate (1:2) | CHLOROQUINE DIPHOSPHATE [MI] | NCGC00093746-02 | Aralen phosphate | CHLOROQUINE PHOSPHATE (MART.) | HMS2096N17 | UNII-6E17K3343P | CHLOROQUINE PHOSPHATE (US

Specifiche e purezza

≥99%

Meccanismi biochimici e fisiologici

Antimalarial agent. Inhibits tumor cell growth and metastasis and induces apoptosis in vitro . Binds to Fe(II)-protoporphyrin IX (FP) to form FP-chloroquine complex resulting in cell lysis and parasite cell autodigestion.

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Meccanismo d'azione

Ferriprotoporphyrin IX inhibitor

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purezza

≥99%

Nomi e identificatori

Pubchem Sid

504753930

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504753930

Sorrisi canonici

CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O

IUPAC Name

4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid

InChIKey

QKICWELGRMTQCR-UHFFFAOYSA-N

INCHI

1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)

Isomeri SMILES

CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O

WGK Germania

3

RTECS

VB2450000

PubChem CID

64927

Peso molecolare

515.86

Beilstein

4223142

Reaxy-Rn

4223142

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Quinolines and derivatives
      • Subclass Aminoquinolines and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Quinolines and derivatives
• Subclass: Aminoquinolines and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: 4-aminoquinolines
• Alternative Parents: Chloroquinolines Secondary alkylarylamines Aminopyridines and derivatives Organic phosphoric acids and derivatives Benzenoids Aryl chlorides Heteroaromatic compounds Trialkylamines Azacyclic compounds Organopnictogen compounds Organochlorides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 4-aminoquinoline - Haloquinoline - Chloroquinoline - Aminopyridine - Secondary aliphatic/aromatic amine - Aryl chloride - Aryl halide - Organic phosphoric acid derivative - Pyridine - Benzenoid - Heteroaromatic compound - Tertiary amine - Tertiary aliphatic amine - Secondary amine - Azacycle - Hydrocarbon derivative - Organonitrogen compound - Organochloride - Organic oxide - Organohalogen compound - Organopnictogen compound - Organic oxygen compound - Amine - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as 4-aminoquinolines. These are organic compounds containing an amino group attached to the 4-position of a quinoline ring system.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: DMSO <1 mg/mL Water 100 mg/mL Ethanol <1 mg/mL
• Sensibilità: Light sensitive
• Punto di fusione (°C): 199°C
• Peso molecolare: 515.900 g/mol
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 8
• Exact Mass: 515.135 Da
• Monoisotopic Mass: 515.135 Da
• Topological Polar Surface Area: 184.000 Ų
• Heavy Atom Count: 32
• Formal Charge: 0
• Complexity: 358.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

Domande frequenti

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 50-63-5, the molecular formula is C18H26ClN3·2H3PO4, and the molecular weight is 515.86 g/mol. InChIKey QKICWELGRMTQCR-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.