Cilostazol (OPC-13013) - Moligand™, 10mM in DMSO , Phosphodiesterase 3A inhibitor, CAS No.73963-72-1, Phosphodiesterase 3A inhibitor

CAS: 73963-72-1 Cat. No.: C408872 Formula: C₂₀H₂₇N₅O₂ Peso molecolare: 369.46 Numero EC: 689-122-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Cilostazol (OPC-13013) is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor withIC50of 0.2 μM and inhibitor of adenosine uptake.
In vitro

Cilostazol (OPC-13013) is a 2-oxo-quinoline derivative with antithrombotic, vasodilator, antimitogenic and cardiotonic properties. The vasodilatory and antiplatelet actions of cilostazol are due mainly to the inhibition of phosphodiesterase 3 (PDE3) and subsequent elevation of intracellular cAMP levels. Cilostazol inhibits platelet aggregation. Cilostazol also possesses the ability to inhibit adenosine uptake. Elevation of interstitial adenosine by cilostazol in the heart is shown to reduce increases in cAMP caused by the PDE3-inhibitory action of cilostazol, thus attenuating the cardiotonic effects. Cilostazol is reported to inhibit smooth muscle cell proliferation. Cilostazol relaxes vascular smooth muscle and causes vasodilatation. Cilostazol inhibits the cytokine-induced expression of monocyte chemoattractant protein-1 (MCP-1). Cilostazol reduced plasma triglycerides and raised plasma HDL-cholesterol .

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Cilostazol (OPC-13013) is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Meccanismo d'azione

Phosphodiesterase 3A inhibitor

Proprietà del prodotto

ALogP

3.1

Nomi e identificatori

Isomeri SMILES

C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4

WGK Germania

2

RTECS

VC8277500

Peso molecolare

369.46

Reaxy-Rn

3632107

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3632107&ln=

Obiettivi associati (umani)

PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A (2 Activities)

Discover Target: PDE3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE3B Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase B (1 Activities)

Discover Target: PDE3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 74 mg/mL (199.76 mM); Water: Insoluble; Ethanol: Insoluble
• Punto di fusione (°C): 160 °C