Cl-NQTrp - Moligand™, ≥98% , CAS No.185351-23-9

CAS: 185351-23-9 Cat. No.: C649604 Molecular Weight: 394.81

GRADE & PURITY Moligand™, ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein.

In Vitro

Cl-NQTrp efciently disassembled pre-formed PHF6 peptide fbrils. Cl-NQTrp has the potential to induce conformational changes in PHF6 peptide oligomers. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cl-NQTrp could be a unique potential therapeutic for AD since it targets aggregation of both Aβ and tau. Cl-NQTrp significantly alleviates the shorter life span of htau-expressing flies, leading to 58% viability on day 29. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Virgin females, carrying either the eye GMR -Gal4 driver or the pan-neuronal driver elav c155 -Gal4 on chromosome X, were collected and crossed with males carrying UAS-h tau on the 2nd chromosome or with wild-type Oregon-R (OR) males as a control. Dosage: 0.75 mg/mL. Administration: Dripped every other day. Result: Inhibited PHF6 aggregation and ameliorates eye neurodegeneration Drosophila overexpressing the human tau protein (htau).

Form:Solid

Specifications

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Purity

≥98%

Names and Identifiers

• Canonical Smiles: ClC(C(C1=C(C=CC=C1)C2=O)=O)=C2N[C@H](C(O)=O)CC3=CNC4=C3C=CC=C4
• Molecular Weight: 394.81

Chemical and Physical Properties

• Solubility: DMSO : 250 mg/mL (633.22 mM; Need ultrasonic)