Clindamycin HCl - 10mM in DMSO , Bacterial 70S ribosome inhibitor, CAS No.21462-39-5, Bacterial 70S ribosome inhibitor

CAS: 21462-39-5 Cat. No.: C409273 Formula: C₁₈H₃₃ClN₂O₅S · HCl Peso molecolare: 461.44 Numero EC: 244-398-6

GRADE & PURITY 10mM in DMSO

Synonyms

(L-​threo-​α-​D-​galacto-​Octopyranoside, methyl 7-​chloro-​6,​7,​8-​trideoxy-​6-​[[[(2S,​4R)​-​1-​methyl-​4-​propyl-​2-​pyrrolidinyl]​carbonyl]​amino]​-​1-​thio-​, hydrochloride (1:1))

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Clindamycin HCl Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal , used for the treatment of bacterial infections.
In vitro

Clindamycin is a classical inhibitor of bacterial protein synthesis, by binding to the 23S ribosomal RNA of the 50S ribosomal subunit.

In vivo

Clindamycin hydrochloride results in fast absorption after oral administration in dogs, with a mean absorption time (MAT) of 0.87 hour, and bioavailability is 72.55%. Clindamycin hydrochloride results in total clearance (CL) of Clindamycin after both IV and oral administration (0.503 vs. 0.458 L/h/kg) in dogs. Clindamycin hydrochloride results in volume of distribution at steady-state (IV) at 2.48 L/kg, indicating a wide distribution of clindamycin in body fluids and tissues. Clindamycin serum concentrations after IV and oral administration remain above 0.5 μg/mL approximately for 10 hours. Clindamycin hydrochloride significantly reduces oral malodor from the dogs\' baseline levels through 42 days. Clindamycin hydrochloride also results in significant reductions in dental plaque, dental calculus, and gingival bleeding in dogs. Clindamycin hydrochloride (2.5 mg/lb), after ultrasonic scaling, root planing, and polishing (USRP) , has a significant effect on plaque and pocket depth measures of periodontal disease but not on gingivitis in canine. Clindamycin hydrochloride results in complete remission ratio of 71.4% (15/21) in dogs with canine superficial bacterial pyoderma after treat within 14 to 28 days.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:

Specifications

Sinonimi

(L-​threo-​α-​D-​galacto-​Octopyranoside, methyl 7-​chloro-​6,​7,​8-​trideoxy-​6-​[[[(2S,​4R)​-​1-​methyl-​4-​propyl-​2-​pyrrolidinyl]​carbonyl]​amino]​-​1-​thio-​, hydrochloride (1:1))

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Meccanismo d'azione

Bacterial 70S ribosome inhibitor

Nomi e identificatori

• Isomeri SMILES: CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@H](C)Cl.Cl
• CAS alternativo: 58207-19-5
• Peso molecolare: 461.44

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 73 mg/mL (98.02 mM); Water: Insoluble; Ethanol: Insoluble

Riferimenti

1. Tong Shao, Xiaoshuang Wang, Rentian Guan, Suyuan Zeng, Rui Li, Min Hong, Qiaoli Yue.  (2023)  Carbonized polymer dots for the sensitive and selective analysis of chlortetracycline based on the aggregation induced emission.  NEW JOURNAL OF CHEMISTRY,  47  (37): (17293-17302).  [PMID:] [10.1039/D3NJ02474A]

2. Wei Xinjie, Luo Xuan, Xu Shuai, Xi Fengna, Zhao Tingting.  (2022)  A Flexible Electrochemiluminescence Sensor Equipped With Vertically Ordered Mesoporous Silica Nanochannel Film for Sensitive Detection of Clindamycin.  Frontiers in Chemistry,      [PMID:35464210] [10.3389/fchem.2022.872582]

3. Chang Liu, Diandian Deng, Di Xu, Kang Wu, Hong Yang, Kang Zhao, Jianguo Li, Anping Deng.  (2018)  Development of a monoclonal antibody based-ELISA for the detection of chloramphenicol in shrimp, feed and milk samples and validation by LC-MS/MS coupled with immunoaffinity clean-up.  Analytical Methods,  11  (4): (507-516).  [PMID:] [10.1039/C8AY02284D]

4. Xin Liu, Zhenlong Zhang, Huafang Zhang, Yuefeng Liu, Huiping Gao, Yanli Mao.  (2026)  Triple functional passivation of SnO2 surface defects for highly efficient and stable perovskite solar cells.  Surfaces and Interfaces,      [PMID:] [10.1016/j.surfin.2026.110023]

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 21462-39-5, the molecular formula is C18H34Cl2N2O5S, and the molecular weight is 461.44 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.