Clobetasol propionate - Moligand™, 10mM in DMSO , Glucocorticoid receptor agonist, CAS No.25122-46-7, Glucocorticoid receptor agonist

CAS: 25122-46-7 Cat. No.: C409015 Formula: C₂₅H₃₂ClFO₅ Peso molecolare: 466.97 Numero EC: 246-634-3

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

CGP9555, CCl 4725 | (11β,​16β)​-21-​chloro-​9-​fluoro-​11-​hydroxy-​16-​methyl-​17-​(1-​oxopropoxy)​-​pregna-​1,​4-​diene-​3,​20-​dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Clobetasol propionate Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

CGP9555, CCl 4725 | (11β,​16β)​-21-​chloro-​9-​fluoro-​11-​hydroxy-​16-​methyl-​17-​(1-​oxopropoxy)​-​pregna-​1,​4-​diene-​3,​20-​dione

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

AGONIST

Meccanismo d'azione

Glucocorticoid receptor agonist

Proprietà del prodotto

• ALogP: 3.8

Nomi e identificatori

• Isomeri SMILES: CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CCl
• WGK Germania: 2
• RTECS: TU3725000
• Peso molecolare: 466.97
• Reaxy-Rn: 37811597
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37811597&ln=

Obiettivi associati (umani)

CYP3A4 Tclin Cytochrome P450 3A4 (1 Activities)

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR3C1 Tclin Glucocorticoid receptor (3 Activities)

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A5 Tclin Cytochrome P450 3A5 (5 Activities)

Discover Target: CYP3A5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Rotazione specifica [α]: +99.0 °～ +103.0°(C=1,Dioxane)
• Punto di fusione (°C): 196.0°C-200.0°C

Riferimenti

1. Youfang Huang, Yanyun Li, Qing Luo, Xiaojia Huang.  (2020)  One-step preparation of functional groups-rich graphene oxide and carbon nanotubes nanocomposite for efficient magnetic solid phase extraction of glucocorticoids in environmental waters.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2020.126785]

2. Guihua Gao, Sijia Li, Shuo Li, Yudan Wang, Pan Zhao, Xiangyu Zhang, Xiaohong Hou.  (2017)  A combination of computational−experimental study on metal-organic frameworks MIL-53(Al) as sorbent for simultaneous determination of estrogens and glucocorticoids in water and urine samples by dispersive micro-solid-phase extraction coupled to UPLC-MS/MS.  TALANTA,      [PMID:29332823] [10.1016/j.talanta.2017.12.071]

3. Guozheng Zhao.  (2023)  Multi-Residue Detection of Eight Glucocorticoids by Nano-Au/Fluticasone Propionate Electrochemical Immunosensor.  MOLECULES,  28  (18): (6619).  [PMID:37764395] [10.3390/molecules28186619]

4. Guozheng Zhao.  (2024)  Detection of six glucocorticoids using a nanogold-glucocorticoid receptor-based biosensor.  CHEMICAL PHYSICS LETTERS,      [PMID:] [10.1016/j.cplett.2024.141611]

5. Guozheng Zhao.  (2025)  Simultaneous detection of four glucocorticoids by graphene-chitosan\ nanogold\glucocorticoid receptor bioimmunosensor.  CHEMICAL PHYSICS LETTERS,      [PMID:] [10.1016/j.cplett.2025.142060]

Domande frequenti

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 25122-46-7, the molecular formula is C25H32ClFO5, and the molecular weight is 466.97 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.