Croscarmellose Sodium - JP, Ph.Eur., NF , CAS No.74811-65-7

CAS: 74811-65-7 Cat. No.: C494293 EC Number: 629-739-2 PubChem CID: 17397716

GRADE & PURITY JP, Ph.Eur., NF

Storage

Store at 2-8°C,Argon charged

Shipped In

Wet ice

Overview

C494293-NM, croscarmellose sodium, is a superdisintegrant specifically developed for manufacturing tablets and capsules. Its unique performance attributes have established C494293-NM as a globally accepted product in the pharmaceutical and nutritional industries.

The fibrous nature of C494293-NM possesses a wicking effect, which is responsible for rapid capillary transport into the tablet matrix. As a result, the C494293-NM use level can remain low while still providing superior tablet disintegration properties.

JRS Pharma produces two croscarmellose sodium grades: C494293-NM and C494293-GF (GMO-Free). Their specifications and functional performances are similar.

Benefits:

1.Fast tablet disintegration

2.Good flowability and mixing properties

3.Excellent API stability

4.Performs well in both direct compression and granulation processes

5.Cost-effectiveness

6.Guaranteed supply chain security

Product specifications and parameters:

SKU	Raw Material	GMO free	Loss on Drying	Solvent content	Main Application	Pack Size
C494293-NM-25g	cotton flock		max. 10%	max. 1% MeOH	A cellulose-based superdisintegrant, providing excellent results in tablet disintegration. Used at a level of 1 - 4 % only, it is one of the most efficient superdisintegrants in pharmaceutical technology. C494293-NM can be used in all tableting processes. Especially good for medium soluble actives.	25g
C494293-GF-25g	wood pulp	✓	max. 10%	max. 0.5% EtOH		25g
C494293-GFLM-25g	wood pulp	✓	max. 6%	max. 0.01% EtOH	Grade with less than 6 % moisture for food applications (E468).	25g
C494293-NM-100g	cotton flock		max. 10%	max. 1% MeOH	A cellulose-based superdisintegrant, providing excellent results in tablet disintegration. Used at a level of 1 - 4 % only, it is one of the most efficient superdisintegrants in pharmaceutical technology. C494293-NM can be used in all tableting processes. Especially good for medium soluble actives.	100g
C494293-GF-100g	wood pulp	✓	max. 10%	max. 0.5% EtOH		100g
C494293-GFLM-100g	wood pulp	✓	max. 6%	max. 0.01% EtOH	Grade with less than 6 % moisture for food applications (E468).	100g

Specifications

Specifications & Purity

JP, Ph.Eur., NF

Storage

Store at 2-8°C, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

JP, NF, Ph.Eur.

Names and Identifiers

• Isomeric SMILES: COC1=CC=CC(=C1O)C(=O)OCC2=NC(=NO2)C3=CC=CS3
• PubChem CID: 17397716

Chemical and Physical Properties

• Sensitivity: Moisture sensitive
• Melt Point(°C): >205ºC

References

1. Gu Yuang, Yao Yu, Lou Qiuwen, Zhu Xinyan, Lan Ju, Gao Chenshu, Wu Shuangshuang, Liang Jingjia, Xu Cenglin, Wang Yi, Cheng Heming, Chen Zhong.  (2025)  Model-Dependent Attenuation of Seizures by Cinnabar.  Neuroscience Bulletin,      [PMID:40783890] [10.1007/s12264-025-01480-7]