CX 717 - ≥99% , CAS No.867276-98-0

CAS: 867276-98-0 Cat. No.: C650121 Formula: C₁₁H₁₁N₃O₃ Peso molecolare: 233.22 PubChem CID: 3323368

QUALITÀ & PUREZZA ≥99%

Synonyms

2,1,3-Benzoxadiazol-5-yl-4-morpholinylmethanone | 2,1,3-benzoxadiazol-5-yl(morpholin-4-yl)methanone | CX 717 | CX 717 (pharmaceutical) | EX-A6414 | SCHEMBL243542 | DB05047 | starbld0003244 | AKOS040758937 | DTXSID301241632 | Benzo[c][1,2,5]oxadiazol-5-yl(

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

CX 717 is a positive allosteric modulator of AMPA receptor. Antidepressant-like effect. CX 717 can be used for the research of adult attention deficit hyperactivity disorder (ADHD).

In Vivo

CX 717 (CX717; 20 mg/kg) has a rapid (30 min) but short-lasting (up to 24 h) antidepressantlike effect in the forced swim test.CX 717 also produces a rapid (up to 1 h) increase of brain-derived neurotrophic factor (BDNF) and a more sustained (up to 6 h) increase of p11. Intra-cortical infusion of CX 717 (85 mM) increases the efflux of noradrenaline, dopamine, and serotonin, but not glutamate. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats weighing 280-350 gDosage: 20 mg/kg (administered at 1 mL/kg) Administration: Intraperitoneal (i.p.) injection Result: Evoked antidepressant-like effects (20 mg/kg, i.p.) did not alter the extracellular concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT) and glutamate in the medial prefrontal cortex (mPFC).

Form:Solid

Specifiche

Sinonimi

2,1,3-Benzoxadiazol-5-yl-4-morpholinylmethanone | 2,1,3-benzoxadiazol-5-yl(morpholin-4-yl)methanone | CX 717 | CX 717 (pharmaceutical) | EX-A6414 | SCHEMBL243542 | DB05047 | starbld0003244 | AKOS040758937 | DTXSID301241632 | Benzo[c][1,2,5]oxadiazol-5-yl(

Specifiche e purezza

≥99%

Meccanismi biochimici e fisiologici

CX 717 is a positive allosteric modulator of AMPA receptor . Antidepressant-like effect. CX 717 can be used for the research of adult attention deficit hyperactivity disorder (ADHD).

Condizioni di conservazione di stoccaggio

Protected from light,Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

AGONIST

Purezza

≥99%

Nomi e identificatori

Sorrisi canonici

C1COCCN1C(=O)C2=CC3=NON=C3C=C2

IUPAC Name

2,1,3-benzoxadiazol-5-yl(morpholin-4-yl)methanone

InChIKey

KFRQROSRKSVROW-UHFFFAOYSA-N

INCHI

1S/C11H11N3O3/c15-11(14-3-5-16-6-4-14)8-1-2-9-10(7-8)13-17-12-9/h1-2,7H,3-6H2

Isomeri SMILES

C1COCCN1C(=O)C2=CC3=NON=C3C=C2

PubChem CID

3323368

Peso molecolare

233.22

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Benzoxadiazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Benzoxadiazoles
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzoxadiazoles
• Alternative Parents: Morpholine carboxylic acids and derivatives Benzenoids Tertiary carboxylic acid amides Heteroaromatic compounds Furazans Oxacyclic compounds Dialkyl ethers Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzoxadiazole - Morpholine-4-carboxylic acid or derivatives - Morpholine - Benzenoid - Oxazinane - Azole - Furazan - Heteroaromatic compound - Tertiary carboxylic acid amide - Oxadiazole - Carboxamide group - Carboxylic acid derivative - Dialkyl ether - Ether - Oxacycle - Azacycle - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as benzoxadiazoles. These are organic compounds containing a benzene fused to an oxadiazole ring (a five-membered ring with two carbon atoms, one nitrogen atom, and one oxygen atom).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: DMSO : 50 mg/mL (214.39 mM; ultrasonic and warming and heat to 60°C)
• Peso molecolare: 233.220 g/mol
• XLogP3: 0.300
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 233.08 Da
• Monoisotopic Mass: 233.08 Da
• Topological Polar Surface Area: 68.500 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 294.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1