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Cyclotraxin B, CAS No.1203586-72-4
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GRADE & PURITY ≥98%
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced TrkB activity with an IC50 of 0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects。
Specifications
Product Name
Cyclotraxin B, CAS No.1203586-72-4
Synonyms
S-1203586-72-4 | Cyclotraxin B acetate | (3S, 6R, 11R, 17S, 20S, 23S, 26S, 32S, 35S)-6-amino-20-(4-aminobutyl)-3-(2-amino-2-oxoethyl)-17-(2-carboxyethyl)-23-[(1R)-1-hydroxyethyl]-26-[(4-hydroxyphenyl)methyl]-32-(2-methylsulfanylethyl)-2, 5, 13, 16, 19, 22, 25, 28, 31, 34-
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50= 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic pr
Sequence
CNPMGYTKEGC(Modifications: Disulfide bridge between 1 - 11)
Action Type
INHIBITOR
CAS
1203586-72-4
Molecule Type
Small molecule
Storage and Shipping
Storage
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
3D Structure
Interactive Chemical Structure Model
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 L2314126 | Certificate of Analysis | Nov 28, 2023 | C288514 |
| L2314127 | Certificate of Analysis | Nov 28, 2023 | C288514 |
| L2314128 | Certificate of Analysis | Nov 28, 2023 | C288514 |
| L2314129 | Certificate of Analysis | Nov 28, 2023 | C288514 |
| L2314130 | Certificate of Analysis | Nov 28, 2023 | C288514 |
| L2314131 | Certificate of Analysis | Nov 28, 2023 | C288514 |
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