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Cys-McMMAF - ≥99% , CAS No.1160590-05-5
Disponibile su ordine
GRADE & PURITY ≥99%
Storage
Protected from light,Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Protected from light,Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Panoramica
Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-DYT2 models).
In Vivo
Cys-McMMAF (0.3 mg/kg, 3 mg/kg; i.v.; single dose) has a poor stability with short decline time in cynomolgus monkeys . Pharmacokinetic Analysis in Nude (nu/nu) Mice Model/IV Dose (mg/kg) C max (ng/mL) T max (hr) AUC 0-336 (ng·h/mL) t 1/2 (day) Non-Tumor 1 0.192 8 14.6 2.1 Tumor 1 0.146 8 28.2 6.0 Non-Tumor 10 0.951 8 58.5 3.0 Tumor 10 0.945 8 81.9/td> 2.9 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
Specifications
Specifiche e purezza
≥99%
Meccanismi biochimici e fisiologici
Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF ( HY-15579 ) via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-D
Condizioni di conservazione di stoccaggio
Protected from light,Store at -20°C
Spedito in
Ice chest + Ice pads
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
Tipo di azione
INHIBITOR
Purezza
≥99%
Nomi e identificatori
| Peso molecolare | 1046.32 |
|---|
Documentazione
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Proprietà chimiche e fisiche
| Solubilità | DMSO : 200 mg/mL (191.15 mM; Need ultrasonic) |
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Calcolatori di soluzioni
Recensioni
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