D-Luciferin potassium - Moligand™, 10 mM in Water , CAS No.115144-35-9

CAS: 115144-35-9 Cat. No.: D1495731 Molecular Weight: 318.41 Beilstein Registry Number: 5416262

GRADE & PURITY Moligand™, 10 mM in Water

Storage

Protected from light,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP. We offer the firefly luciferase, luciferin free acid, as well as its water-soluble sodium salts and potassium salts .

Specifications

Specifications & Purity

Moligand™, 10 mM in Water

Storage

Protected from light, Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• WGK Germany: 3
• Molecular Weight: 318.41
• Beilstein: 5416262
• Reaxy-Rn: 41031268
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=41031268&ln=

References

1. Haiyang Wang, Yixuan Hou, Taian Lin, Ihsan Ullah, Qing Xu, Ye Liu, Taosha Jin, Yangning Zhang, Youyong Yuan.  (2025)  Sono-Responsive Hydrogel for Fractionated PROTAC Release to Alleviate Resistance and Immunosuppression Induced by Multi-Course Postoperative Radiotherapy.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202512954]

2. Lifeng Liu, Junmei Zhang, Shihao Wang, Zhirong He, Xiaohu Wang, Limin Tian, Mingxi Li, Guangyu Long, Siqi Zhu, Zhengyu Jiang, Suxin Li.  (2025)  Reprogramming Macrophage via an Antigen Phagocytosis-Presentation Nanoenhancer for Improved Cancer Immunotherapy.  ACS Nano,      [PMID:40835579] [10.1021/acsnano.5c09460]

3. Ji Chen, Xiya Guo, Yanqiao Ma, Jie Zhou, Ping Li, Mingxin Dong, Jie Du.  (2025)  Selective Activation of Conditionally Replicating Influenza A Virus in Pulmonary Tumors for Enhanced Oncolytic Efficacy and Systemic Safety.  Advanced Healthcare Materials,      [PMID:40879091] [10.1002/adhm.202502017]

4. Shuo Tang, Lujun Wang, Wenjie Lu, Lingzhen Ding, Xia Liu, Yu Tao, Mingchao Xu, Wenyou Fang, Shengqi Chen, Rongfeng Hu.  (2025)  Screening Ganoderma Lucidum Spore Oil-based Oral Solid Self-microemulsion of Paclitaxel for Enhanced Chemotherapeutic Efficacy via Immunomodulation in Colorectal Cancer.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2025.107419]

5. Yunyan Li, Tong Yan, Wenya Chang, Chongjiang Cao, Dawei Deng.  (2019)  Fabricating an intelligent cell-like nano-prodrug via hierarchical self-assembly based on the DNA skeleton for suppressing lung metastasis of breast cancer.  Biomaterials Science,  7  (9): (3652-3661).  [PMID:31169833] [10.1039/C9BM00630C]

6. Xinzi Hu, Guangzhi Li, Chenfan Kong, Lisha Liu, Dashi Deng, Guizhong Xin, Jian Pan, Song Wu, Qifang Lei.  (2024)  Fluorinated chitosan mediated transepithelial delivery of sanguinarine-loaded platinum (IV) prodrug for intravesical instillation therapy of muscle-invasive bladder cancer.  JOURNAL OF CONTROLLED RELEASE,      [PMID:39701454] [10.1016/j.jconrel.2024.12.023]

7. Yuan Li, Huiqin Chen, Qiaofeng Shen, Yingshuang Liu, Pingping Li, Yuqi Ma, Yugang Wang, Shengkai Li, Xueqing Yan, Liyu Liu, Jianwei Shuai, Min Wu, Qi Ouyang, Feng-Ming (Spring) Kong, Gen Yang.  (2025)  Fragment Autoantigens Stimulated T-Cell-Immunotherapy (FAST) as a Fast Autologous Cancer Vaccine.  Advanced Science,      [PMID:40135850] [10.1002/advs.202502937]

8. Ximu Li, Mengyao Ma, Ni An, Xiaoxuan Yao, Guzailinuer Yasen, Mingyuan Zhong, Zheng Jin, Zhonggui He, Yongjun Wang, Hongzhuo Liu.  (2025)  Lipid-Rapamycin Nanovaccines Overcome the Antidrug Antibody Barrier in Biologic Therapies.  ACS Nano,      [PMID:39847793] [10.1021/acsnano.4c11928]

9. Wei Cheng, Zhiran Duan, Han Chen, Yanjun Wang, Chao Wang, Yuqing Pan, Jie Wu, Ning Wang, Haijing Qu, Xiangdong Xue.  (2025)  Macrophage membrane-camouflaged pure-drug nanomedicine for synergistic chemo- and interstitial photodynamic therapy against glioblastoma.  Acta Biomaterialia,      [PMID:39800099] [10.1016/j.actbio.2025.01.016]

10. Chenxu Zhu, Chuang Li, Yibo Du, Shi Chen, Xingliang Liu, Lixin Liu, Yongming Chen.  (2025)  Precise Oligopeptides Block CCDC25 Interaction with DNA in Neutrophil Extracellular Traps Inhibiting Tumor Metastasis.  ACS Applied Materials & Interfaces,      [PMID:40000243] [10.1021/acsami.5c00670]

11. Yixuan Wang, Songyu Yang, Shengbin Chen, Yingbing Zuo, Xiaoyu Mu, Hongmei Zhou, Yufei Yao, Xiaoping Peng, Wenjuan Li.  (2025)  UPLC-Q-TOF/MS-based serum metabolomics revealed anti-tumor mechanism of ethanol-soluble acidic components from Camellia oleifera cake and synergy with PD-1 inhibitor.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.106005]

12. Qianqian Wang, Xin Yuan, Cuijuan Liu, Ying Huang, Lin Li, Yimin Zhu.  (2025)  Peptide-based CAR-NK cells: A novel strategy for the treatment of solid tumors.  BIOCHEMICAL PHARMACOLOGY,      [PMID:39761877] [10.1016/j.bcp.2025.116741]

13. Lei Huang, Xinbo Li, Hongyan Zhang, Feng Liu, Zheng Dai, Fang Xiao, Lin Wang, Zheng Wang.  (2025)  Zinc Ion-Coordinated Sericin Calcium Phosphate Nanovaccines Induce Hyperactive Dendritic Cells and Synergistic Activation of T Cells for Cancer Immunotherapy.  ACS Nano,      [PMID:40177975] [10.1021/acsnano.4c17491]

14. Yiping Liang, Xinyi Cao, Zhiwen Ma, Chengge Ma, Haitong Wen, Meng Li, Hangyi Wu, Ting Liu, Xiaoyu Lu, Huixia Lv.  (2025)  Enterohepatic circulation-inspired nano-platform for less-hepatotoxicity hepatocellular carcinoma therapy.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:40354905] [10.1016/j.ijpharm.2025.125693]

15. Haihong Yang, Zhan Gao, Yizi Zhou, Xueer Ge, Xiaorong Pan, Jiakun Li, Zhihui Zhang, Xuanli Jin, Guotao Liu, Zepeng He, Hong Liu, Zhijia Liu, Lixin Liu, Yongming Chen.  (2025)  Tertiary amine N-oxide zwitterionic lipids facilitate muscle-selective mRNA vaccine delivery for enhancing cDC1-mediated antitumor efficacy.  JOURNAL OF CONTROLLED RELEASE,      [PMID:40436347] [10.1016/j.jconrel.2025.113892]

16. Huilan He, Yun Zheng, Jinlong Ji, Chunlian Ye, Yu Sun, Yuwei Peng, Ying Zhang, Zhiyuan Zhong.  (2025)  Liposomal all-trans retinoic acid boosts anti-tumor immunity of radiotherapy via mitigating cancer stemness and remedying tumor microenvironment.  JOURNAL OF CONTROLLED RELEASE,      [PMID:40602432] [10.1016/j.jconrel.2025.113995]

17. Song Ruilian, Wang Yixiang, Li Yanjun, Wang Qifei, Zhang Siyu, Sun Dongfa, Sun Genlou, Sun Longqing, Ren Xifeng.  (2025)  Unraveling the regulatory network of barley grain metabolism through the integrative analysis of multiomics and mQTL.  Nature Communications,  16  (1): (1-20).  [PMID:40593515] [10.1038/s41467-025-60501-1]

18. Wei Liu, Meihui Zhang, Huiyuan Lv, Chuanxu Yang.  (2025)  Formulation-Driven Optimization of PEG-Lipid Content in Lipid Nanoparticles for Enhanced mRNA Delivery In Vitro and In Vivo.  Pharmaceutics,  17  (8): (950).  [PMID:40870973] [10.3390/pharmaceutics17080950]

19. Ciliang Guo, Tian Gao, Bin Xue, Louqian Zhang, Shuo Wang, Rongrong Xiao, Lingkai Kong, Yuxin Zhang, Qilei Xin, Yi Cao, Xiaosong Gu, Chunping Jiang, Junhua Wu.  (2025)  In situ extended immune activation instantly after tumor resection by oncolytic virus controls postoperative tumor recurrence.  Cell Reports Medicine,      [PMID:41045932] [10.1016/j.xcrm.2025.102399]

20. Qing Liang, Yue Peng, Linyao Zhao, Zhenlin Yang, Xiaowei Chen, Jinfei Li, Zhiyuan Wu, Kun Chen, Bolun Zhou, Yang Liu, Bin Hu, Chunfeng Qu, Moyan Zhang, Shugeng Gao.  (2025)  Pulmonary macrophage-targeted RNAi and mRNA co-delivery via SORT lipid nanoparticles enhances immunotherapy in lung cancer.  JOURNAL OF CONTROLLED RELEASE,      [PMID:41371503] [10.1016/j.jconrel.2025.114519]

21. Wang Jia, Wang Zhiji, Li Kaiming, Liu Yue, Tang Chunming, Gao Huimin, Zhou Yupeng, Wang Pengpeng, Wu Haisi, Liu Pengfei, Xu Huae, Li Xiaolin.  (2025)  Tumor targeting dendritic nanocarrier with immunogenic cell death inducing and TIGIT blockade for synergistic chemo-immunotherapy against TNBC.  JOURNAL OF NANOBIOTECHNOLOGY,  23  (1): (759).  [PMID:41354959] [10.1186/s12951-025-03875-0]

22. Gan Ziqi, Huang Jing, Duan Shuting, Lin Minzhao, Deng Shaohui, Huang Sicong, Wang Jiachen, Shuai Xintao, Xiao Zecong.  (2025)  αPD-1-conjugated acid-cleavable nanodrugs overcomes cellular immunotherapy barriers in pancreatic tumors.  Nature Communications,      [PMID:41398151] [10.1038/s41467-025-67254-x]

23. Liao Fangli, Tong Yanran, Sun Hua, Chen Sen, Wen Siyang, Du Yan-e, Jiang Linshan, Huang Tong, Liu Manran, Chen Weixian, Yang Liping.  (2026)  Nerves Stimulates Crosstalk between Gastric Cancer and Group 3 Innate Lymphoid Cells to Enhance Immunosuppression.  CANCER RESEARCH,      [PMID:41534088] [10.1158/0008-5472.CAN-25-3092]

24. Li Li, Weijia Huang, Zhenyang Zhao, Yuan Gao, Rui Zhang, Zhonghao Liao, Yuxin Hu, Qing Ma, Yang Yang, Yongjun Wang, Hongzhuo Liu.  (2026)  Cholesterolated Rapamycin Prodrug Liposomes Induce Antigen-Specific Tolerance and Enable AAV Redosing.  MOLECULAR PHARMACEUTICS,      [PMID:41674289] [10.1021/acs.molpharmaceut.5c01748]

25. Fangzhou Yang, Yunqian Lu, Xiaoxue Lang, Lina Sun, Hang Zou, Ziting Zhou, Yaoyao Guo, Yifei Guo, Xiangtao Wang, Meihua Han.  (2026)  Homologous Tumor Cell-Derived Delivery of Doxorubicin via Liquid Nitrogen-Treated 4T1 Cells for Targeted Breast Cancer Therapy.  MOLECULAR PHARMACEUTICS,      [PMID:41711552] [10.1021/acs.molpharmaceut.5c01664]

26. Kiet Le Anh Cao, Oktaviardi Bityasmawan Abdillah, Tomoyuki Hirano, Eka Lutfi Septiani, Takashi Ogi.  (2026)  Sustainable Porous Carbon Derived from Lignin for High‐Performance CO2 Capture.  Chemistry-An Asian Journal,  21  (4): (e00988).  [PMID:41730805] [10.1002/asia.202500988]

27. Xuanzhi Luo, Yuan Zeng, Xue Wang, Mujin Li, Ya-Lei Wang, Tiantian Peng, Cuiyan Ma, Qian Hua.  (2026)  18ï ¢-Glycyrrhetinic acid suppresses glioblastoma by regulating p38 signaling pathway: an integrative approach combining network analysis, transcriptomics, and experimental assessment.  Frontiers in Pharmacology,      [PMID:41782932] [10.3389/fphar.2026.1727072]

28. Lizhou Lin, Xiao Li, Wenyun Guo, Jirong Xie, Xiaolong Li, Xin Guan, Chongke Zhao, HaoHao Yin, Huixiong Xu.  (2026)  LIFUS-driven engineered bacteria reprogram immunosuppressive niches via mechano-NOTCH signaling.  Cell Reports Medicine,      [PMID:41806839] [10.1016/j.xcrm.2026.102658]

29. Zhang Zhe, Xiao Bing, Jiang Yupeng, Niu Lixia, Wang Li, Cai Juan.  (2026)  UBC9-mediated SUMOylation of CORO1C drives lung adenocarcinoma progression via Arp2/3-dependent cytoskeletal remodeling.  Cell Death & Disease,      [PMID:] [10.1038/s41419-026-08653-w]

30. Meichang Feng, Weiwei Liu, Xiumin Chen, Linghan Huang, Xuan Peng, Yue Li, Shiwu Gao, Zhaoli Lin, Liping Xu, Jinlong Guo.  (2026)  A hierarchical ScMYB11L–ScZAT1–ScDREB1A module defines a derepression pathway for cold-response regulation in sugarcane.  Plant Stress,      [PMID:] [10.1016/j.stress.2026.101340]