Name: Dantrolene sodium salt - 10mM in DMSO , Ryanodine receptor 3 antagonist, CAS No.14663-23-1, Ryanodine receptor 3 antagonist
SKU: D421701
Availability: InStock

Dantrolene sodium salt - 10mM in DMSO , Ryanodine receptor 3 antagonist, CAS No.14663-23-1, Ryanodine receptor 3 antagonist

CAS: 14663-23-1 Cat. No.: D421701 Formula: C₁₄H₉N₄NaO₅ Peso molecolare: 336.23 Numero EC: 238-706-8

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Dantrolene sodium salt - 10mM in DMSO CAS No(14663-23-1) by Aladdin Scientific

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Disponibile su ordine

GRADE & PURITY 10mM in DMSO

Synonyms

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica Specifications Nomi e identificatori Documentazione Advanced Data Taxonomic Classification Struttura 3D Obiettivi associati (umani) Obiettivi associati (non umani) Meccanismi d'azione Certificati (CoA, COO, BSE/TSE e tabella di analisi) Proprietà chimiche e fisiche Calcolatori di soluzioni Recensioni

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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Panoramica

Dantrolene is a small molecule inhibitor of the Ryanodine receptor and a calcium channel protein inhibitor.Blockade of Ca2+ release from the sarcoendoplasmic reticulum, strongly related to excitation and contraction of muscles, generates a muscle relaxant effect correlated with Dantrolene. The neurotoxicity presented by pronounced glutamate activity is correlated to excessive rises in cytoplasmic Ca2+ levels, and Dantrolene is accordingly indicated as a neuroprotective agent against neurotrasmitter-induced excitotoxicity. Dantrolene, Sodium Salt is an inhibitor of RyR-1 and RyR-3.
A calcium channel protein inhibitor.

Specifications

Sinonimi

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Ryanodine receptor antagonist. Calcium channel inhibitor. Reduces calcium flux across the sarcoplasmic reticulum. Displays selectivity for RYR1 and RYR3 over RYR2. Crosses the blood-brain barrier and active in vivo.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

ANTAGONIST

Meccanismo d'azione

Ryanodine receptor 3 antagonist

Nomi e identificatori

Pubchem Sid

528769285

Sorrisi canonici

C1C(=NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].[Na+]

IUPAC Name

sodium;3-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]-2-oxo-4H-imidazol-5-olate

InChIKey

KSRLIXGNPXAZHD-HAZZGOGXSA-M

INCHI

1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;

Isomeri SMILES

C1C(=NC(=O)N1/N=C/C2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].[Na+]

WGK Germania

RTECS

MU3875000

Peso molecolare

336.23

Reaxy-Rn

5698800

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5698800&ln=

Documentazione

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Classe Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Classe	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives
Direct Parent	Alpha amino acids and derivatives
Alternative Parents	Nitrobenzenes Nitroaromatic compounds Imidazolinones Furans Heteroaromatic compounds N-acylimines Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Azacyclic compounds Organic oxoazanium compounds Organic oxides Hydrocarbon derivatives Organic sodium salts Organic zwitterions Carbonyl compounds Organopnictogen compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Alpha-amino acid or derivatives - Nitrobenzene - Nitroaromatic compound - Monocyclic benzene moiety - Imidazolinone - Benzenoid - Furan - 2-imidazoline - Heteroaromatic compound - C-nitro compound - Organic nitro compound - N-acylimine - Oxacycle - Azacycle - Organic oxoazanium - Organic alkali metal salt - Allyl-type 1,3-dipolar organic compound - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organoheterocyclic compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Carbonyl group - Organic zwitterion - Organic sodium salt - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organic salt - Organic nitrogen compound - Aromatic heteromonocyclic compound
Descrizione	This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Struttura 3D

Obiettivi associati (umani)

ACHE Tclin Acetylcholinesterase (18204 Activities)

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HL-60 (67320 Activities)

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SMN1 Tchem Survival motor neuron protein (34246 Activities)

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BLM Tchem Bloom syndrome protein (4248 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

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PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

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MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

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ATXN2 Tbio Ataxin-2 (54410 Activities)

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RAN Tchem GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 (21853 Activities)

Discover Target: RAN

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KPNB1 Tbio Importin subunit beta-1/Snurportin-1 (25097 Activities)

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Obiettivi associati (non umani)

Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

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Meccanismi d'azione

Certificati (CoA, COO, BSE/TSE e tabella di analisi)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

1 results found

Lot Number	Certificate Type	Data	Oggetto
B2314004	Certificate of Analysis	Oct 26, 2026	D421701

Proprietà chimiche e fisiche

Peso molecolare	336.230 g/mol
XLogP3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	336.047 Da
Monoisotopic Mass	336.047 Da
Topological Polar Surface Area	127.000 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	536.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	2

Calcolatori di soluzioni

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Dantrolene sodium salt - 10mM in DMSO , Ryanodine receptor 3 antagonist, CAS No.14663-23-1, Ryanodine receptor 3 antagonist

Storage & shipping

Quality documents

Literature proof

Panoramica

Specifications

Documentazione

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Recensioni dei clienti

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