Decamethonium Bromide - Moligand™, 10mM in DMSO , Muscle-type nicotinic acetylcholine receptor partial agonist, CAS No.541-22-0, Muscle-type nicotinic acetylcholine receptor partial agonist

CAS: 541-22-0 Cat. No.: D408329 Formula: C₁₆H₃₈Br₂N₂ Peso molecolare: 418.30 Numero EC: 208-772-2

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

1,10-Decanediaminium, N1,N1,N1,N10,N10,N10-hexamethyl-, bromide (1:2)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Decamethonium Bromide is a nicotinicAChRpartial agonist andneuromuscularblocking agent.
In vitro

Decamethonium (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis. Decamethonium, which has a short action time, is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. In the motor endplate, it causes depolarization, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle. In the process of binding, decamethonium actually activates (depolarizes) the motor endplate, but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥100%

Specifications

Sinonimi

1,10-Decanediaminium, N1,N1,N1,N10,N10,N10-hexamethyl-, bromide (1:2)

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

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Grado

Moligand™

Tipo di azione

PARTIAL AGONIST

Meccanismo d'azione

Muscle-type nicotinic acetylcholine receptor partial agonist

Nomi e identificatori

• Isomeri SMILES: C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C.[Br-].[Br-]
• WGK Germania: 3
• RTECS: BP5950000
• Peso molecolare: 418.30
• Reaxy-Rn: 3728288
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3728288&ln=

Obiettivi associati (umani)

ACHE Tclin Acetylcholinesterase (1 Activities)

Discover Target: ACHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 59 mg/mL (198.82 mM); Ethanol: 2 mg/mL (6.73 mM); Water: Insoluble