Deferiprone - Moligand™, 10 mM in DMSO , CAS No.30652-11-0

CAS: 30652-11-0 Cat. No.: D1499381 Formula: C₇H₉NO₂ Peso molecolare: 139.15 Beilstein Registry Number: 21(5)12,114 Numero EC: 629-275-0

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Deferiprone is a potent, orally active, brain-penetrant, cell-penetrant, skin-permeable, free iron chelating agent. Deferiprone inhibits the proliferation and migration, and stimulates apoptosis in tumor cell. Deferiprone has antianemic, neuroprotective, anti-inflammatory, antioxidant, and antidotal activity. Deferiprone can be used in cancer , cardiovascular disease , infection , inflammation, and neurological disease study .

Specifications

Specifiche e purezza

Moligand™, 10 mM in DMSO

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Proprietà del prodotto

• ALogP: 0.5

Nomi e identificatori

• Isomeri SMILES: CC1=C(C(=O)C=CN1C)O
• WGK Germania: 3
• RTECS: UU7785940
• Peso molecolare: 139.15
• Beilstein: 21(5)12,114
• Reaxy-Rn: 1447108
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1447108&ln=

Proprietà chimiche e fisiche

• Punto di fusione (°C): 272-275°C

Riferimenti

1. Jiajia Luo, Yao Li, Yaru Li, Xuefei Chen, Panyu Du, Zheng Wang, Aixian Tian, Yanjun Zhao.  (2023)  Reversing Ferroptosis Resistance in Breast Cancer via Tailored Lipid and Iron Presentation.  ACS Nano,      [PMID:38055669] [10.1021/acsnano.3c08485]

2. Tiantian Chen, Yan Qin, Yao Li, Yaru Li, Jiajia Luo, Lanlan Fan, Meiyu Feng, Zheng Wang, Yanjun Zhao.  (2023)  Chiral Polymer Micelles Alleviate Adriamycin Cardiotoxicity via Iron Chelation and Ferroptosis Inhibition.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202300689]

3. Li Xie, Wenjie Chen, Qifang Chen, Yang Jiang, Erqun Song, Xiaokang Zhu, Yang Song.  (2022)  Synergistic hydroxyl radical formation, system XC- inhibition and heat shock protein crosslinking tango in ferrotherapy: A prove-of-concept study of “sword and shield” theory.  Materials Today Bio,      [PMID:35865409] [10.1016/j.mtbio.2022.100353]

4. Lidong Yu, Mingyue He, Sihan Liu, Xinyue Dou, Li Li, Ning Gu, Bingsheng Li, Zhiguo Liu, Guixue Wang, Jianglin Fan.  (2021)  Fluorescent Egg White-Based Carbon Dots as a High-Sensitivity Iron Chelator for the Therapy of Nonalcoholic Fatty Liver Disease by Iron Overload in Zebrafish.  ACS Applied Materials & Interfaces,      [PMID:34756030] [10.1021/acsami.1c14674]

5. Zhou Qiao-Mei, Lu Yuan-Fei, Zhou Jia-Ping, Yang Xiao-Yan, Wang Xiao-Jie, Yu Jie-Ni, Du Yong-Zhong, Yu Ri-Sheng.  (2021)  Self-amplification of oxidative stress with tumour microenvironment-activatable iron-doped nanoplatform for targeting hepatocellular carcinoma synergistic cascade therapy and diagnosis.  JOURNAL OF NANOBIOTECHNOLOGY,  19  (1): (1-18).  [PMID:34749740] [10.1186/s12951-021-01102-0]

6. Xiaojiao Zheng, Xu Wang, Zifang Ding, Wei Li, Ying Peng, Jiang Zheng.  (2021)  Metabolic activation of deferiprone mediated by CYP2A6.  XENOBIOTICA,      [PMID:34006188] [10.1080/00498254.2021.1931729]

7. Wendi Han, Chenfang Miao, Xintian Zhang, Yinning Lin, Xiaoli Hao, Zhengjun Huang, Shaohuang Weng, Xinhua Lin, Xianzhong Guo, Jianyong Huang.  (2021)  A signal-off fluorescent strategy for deferasirox effective detection using carbon dots as probe and Cu2+ as medium.  ANALYTICA CHIMICA ACTA,      [PMID:34535261] [10.1016/j.aca.2021.338853]

8. Xueyang Jin, Ming Zhang, Jinghui Lu, Ximeng Duan, Jinyao Chen, Yue Liu, Wenqiang Chang, Hongxiang Lou.  (2021)  Hinokitiol chelates intracellular iron to retard fungal growth by disturbing mitochondrial respiration.  Journal of Advanced Research,      [PMID:35024181] [10.1016/j.jare.2021.06.016]

9. Qiongtao Song, Ying Zhao, Yanrong Yang, Xue Han, Junguo Duan.  (2020)  Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-κB activation.  TOXICOLOGY AND APPLIED PHARMACOLOGY,      [PMID:33285147] [10.1016/j.taap.2020.115361]

10. Xiaokang Zhu, Li Xie, Jinming Tian, Yang Jiang, Erqun Song, Yang Song.  (2024)  A multi-mode Rhein-based nano-platform synergizing ferrotherapy/chemotherapy-induced immunotherapy for enhanced tumor therapy.  Acta Biomaterialia,      [PMID:38570106] [10.1016/j.actbio.2024.03.030]

11. Juanlong Li, Yezi Hu, Zewen Shen, Huihui Jin, Rong He, Wenkun Zhu, Guixia Zhao, Zhuoyu Ji, Bin Ma, Xiangke Wang.  (2024)  Efficient uranium(VI) recovery from fluorinated wastewater via deferiprone ligand complexation.  WATER RESEARCH,      [PMID:39631159] [10.1016/j.watres.2024.122884]

12. Yaru Li, Qian Yang, Lanlan Fan, Fang Liu, Yaqi Shang, Baoxin Zhang, Zheng Wang, Yanjun Zhao.  (2024)  Engineering synergistic liposomes against ovarian cancer via concurrent targeting of myeloid cell leukemia-1(MCL-1) and glutamate-cystine antiporter (SLC7A11).  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2024.106358]

13. Lintao Li, Runtian Li, Ruohan Guo, Shuang Guo, Xuan Qiao, Xinru Wu, Peng Han, Yunbo Sun, Xiaoxia Zhu, Zhuona Wu, Hui Gan, Zhiyun Meng, Guifang Dou, Ruolan Gu, Shuchen Liu.  (2024)  Preparation and Evaluation of a Combination of Chelating Agents for the Removal of Inhaled Uranium.  MOLECULES,  29  (23): (5759).  [PMID:39683918] [10.3390/molecules29235759]

Domande frequenti

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 30652-11-0, the molecular formula is C7H9NO2, and the molecular weight is 139.15 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.