Dehydronitrosonisoldipine - 10mM in DMSO , CAS No.87375-91-5

CAS: 87375-91-5 Cat. No.: D656005 Formula: C₂₀H₂₂N₂O₅ Peso molecolare: 370.4 PubChem CID: 71413046

GRADE & PURITY 10mM in DMSO

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Dehydronitrosonisoldipine, a derivative of Nisoldipine , is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic activities. Dehydronitrosonisoldipine inhibits SARM1 and axon degenration (AxD) by covalently modifying cysteines, also inhibits the Vincristine-activated cADPR production in neurons. Dehydronitrosonisoldipine can be used for researching neurodegenerative disorders

In Vitro

Dehydronitrosonisoldipine exhibits an IC 50 of 4 μM in the SARM1-dN-expression cells, and decreases the cellular cADPR in cells expressing SARM1, but not in expressing SAM-TIR cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:SARM1, Calcium Channel

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Dehydronitrosonisoldipine, a derivative of Nisoldipine ( HY-17402 ), is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic

Condizioni di conservazione di stoccaggio

Protected from light,Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

• Isomeri SMILES: CC1=C(C(=C(C(=N1)C)C(=O)OC(C)C(C)C)C2=CC=CC=C2N=O)C(=O)[O-]
• PubChem CID: 71413046
• Peso molecolare: 370.4