Desmethyl ferroquine - ≥98% , CAS No.903546-18-9

CAS: 903546-18-9 Cat. No.: D651014 Molecular Weight: 419.73 PubChem CID: 146048063

GRADE & PURITY ≥98%

Synonyms

7-chloro-N-[[2-(methylaminomethyl)cyclopenta-2,4-dien-1-yl]methyl]quinolin-4-amine;cyclopenta-1,3-diene;iron(2+) | 1-(((7-Chloro-4-quinolinyl)amino)methyl)-2-((methylamino)methyl)ferrocene | SK3X1P41RY | UNII-SK3X1P41RY | Ferrocene, 1-(((7-chloro-4-quinol

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Desmethyl ferroquine (SSR97213) is the active and major metabolite of Ferroquine. Ferroquine is an antimalarial. Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resistant P. falciparum strains

In Vitro

The estimate of the apparent terminal half-life of Ferroquine is 15.9 days. However, the equally active principal metabolite Desmethyl ferroquine (DMFQ) has a longer t 1/2z , with an overall mean estimate of 31.4 days. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Plasmodium

Specifications

Synonyms

7-chloro-N-[[2-(methylaminomethyl)cyclopenta-2, 4-dien-1-yl]methyl]quinolin-4-amine;cyclopenta-1, 3-diene;iron(2+) | 1-(((7-Chloro-4-quinolinyl)amino)methyl)-2-((methylamino)methyl)ferrocene | SK3X1P41RY | UNII-SK3X1P41RY | Ferrocene, 1-(((7-chloro-4-quinol

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Desmethyl ferroquine (SSR97213) is the active and major metabolite of Ferroquine. Ferroquine is an antimalarial. Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resistant P. falciparum strains.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CNCC1=CC=C[C-]1CNC2=C3C=CC(=CC3=NC=C2)Cl.[CH-]1C=CC=C1.[Fe+2]
• IUPAC Name: 7-chloro-N-[[2-(methylaminomethyl)cyclopenta-2,4-dien-1-yl]methyl]quinolin-4-amine;cyclopenta-1,3-diene;iron(2+)
• InChIKey: AKDMMOAFGKYNKP-UHFFFAOYSA-N
• INCHI: 1S/C17H17ClN3.C5H5.Fe/c1-19-10-12-3-2-4-13(12)11-21-16-7-8-20-17-9-14(18)5-6-15(16)17;1-2-4-5-3-1;/h2-9,19H,10-11H2,1H3,(H,20,21);1-5H;/q2*-1;+2
• Isomeric SMILES: CNCC1=CC=C[C-]1CNC2=C3C=CC(=CC3=NC=C2)Cl.[CH-]1C=CC=C1.[Fe+2]
• Alternate CAS: 903546-18-9
• PubChem CID: 146048063
• Molecular Weight: 419.73

Chemical and Physical Properties

• Solubility: DMSO : 2.5 mg/mL (5.96 mM; Need ultrasonic) H2O : 1 mg/mL (2.38 mM; ultrasonic and warming and heat to 80°C)