Dexamethasone Acetate - 10mM in DMSO , Glucocorticoid receptor agonist, CAS No.1177-87-3, Glucocorticoid receptor agonist

CAS: 1177-87-3 Cat. No.: D408718 Formula: C₂₄H₃₁FO₆ Peso molecolare: 434.5 Beilstein Registry Number: 2342608 Numero EC: 214-646-8

QUALITÀ & PUREZZA 10mM in DMSO

Synonyms

NSC 39471 | 16α-Methyl-9α-fluoroprednisolone 21-acetate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Dexamethasone Acetate Dexamethasone (NSC 39471) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
In vitro

Dexamethasone inhibits COX-2 mRNA expression induced by IL-1 in human articular chondrocytes. Dexamethasone suppresses the cyclooxygenase-2 induction by tumor necrosis factor α (TNFα) with an IC50 of 1 nM in MC3T3-E1 cells. Dexamethasone binds to the glucocorticoid receptor and then to the glucocorticoid response element. Dexamethasone (10 μM) induces osteoblastic differentiation of rat bone marrow stromal cell cultures with elevated mRNA expression of alkaline phosphatase osteopontin, bone sialoprotein, and osteocalcin. Dexamethasone (5 μM) treatment decreases proliferation of adult hippocampal neural progenitor cells and SRE-driven gene expression.

In vivo

Dexamethasone (2 mg/kg) reduces the number of the BrdU-labeled hepatocytes by 80% in male Fischer F344 rats. Dexamethasone (2 mg/kg) pretreatment suppresses the expression of both TNF and IL-6 after partial hepatectomy and significantly reduces the proliferative response of the hepatocytes in male Fischer F344 rats. Dexamethasone also severely diminishes the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but does not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. Dexamethasone (100 μg/kg) produces a significant decrease 59.2% of BrdU(+) hippocampal progenitor cells in Sprague–Dawley rats. Dexamethasone (100 μg/kg) decreases ERK activation in granule cell layer in Sprague–Dawley rats.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifiche

Sinonimi

NSC 39471 | 16α-Methyl-9α-fluoroprednisolone 21-acetate

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Dexamethasone (NSC 39471) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

AGONIST

Meccanismo d'azione

Glucocorticoid receptor agonist

Proprietà del prodotto

ALogP

2.8

Nomi e identificatori

Isomeri SMILES

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)C)O)C)O)F)C

WGK Germania

3

RTECS

TU4050000

Peso molecolare

434.5

Beilstein

2342608

Reaxy-Rn

3508291

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3508291&ln=

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 50 mg/mL (79.42 mM); Water: Insoluble; Ethanol: Insoluble
• Rotazione specifica [α]: 87 ° (C=1, Dioxane)
• Punto di fusione (°C): 240°C

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1177-87-3, the molecular formula is C24H31FO6, and the molecular weight is 434.5 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.