Dexelvucitabine - 10mM in DMSO , Human immunodeficiency virus type 1 reverse transcriptase inhibitor, CAS No.134379-77-4, Human immunodeficiency virus type 1 reverse transcriptase inhibitor

CAS: 134379-77-4 Cat. No.: D656143 Molecular Weight: 227.19

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Dexelvucitabine (Reverset; d-d4FC), a Cytidine analog, is an orally active nucleoside reverse transcriptase inhibitor. Dexelvucitabine is a powerful agent against HIV-1-resistant viruses containing a thymidine analog and/or M184V mutation in the viral polymerase. Dexelvucitabine is a 2′-Deoxycytidine antiretroviral agent

In Vivo

Dexelvucitabine (Reverset; d-d4FC; 33.3 mg/kg by i.v. or p.o.) has distribution and elimination half-lives (t 1/2α and t 1/2β , respectively) of 0.7 and 3.6 h in monkeys, respectively. The C max ranges from 21.1 to 47.5 μM. Dexelvucitabine has a favorable pharmacokinetic profile with a long half-life (4.71 and 10.75 h after administration by the intravenous [i.v.] and oral [p.o.] routes, respectively) in woodchucks. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:HIV-1

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Dexelvucitabine (Reverset; d-d4FC), a Cytidine ( HY-B0158 ) analog, is an orally active nucleoside reverse transcriptase inhibitor. Dexelvucitabine is a powerful agent against HIV-1-resistant viruses containing a thymidine analog and/or M184V mutation in

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Human immunodeficiency virus type 1 reverse transcriptase inhibitor

Product Properties

• ALogP: -1.3

Names and Identifiers

• Isomeric SMILES: C1=C[C@@H](O[C@@H]1CO)N2C=C(C(=NC2=O)N)F
• Alternate CAS: 134379-77-4
• MeSH Entry Terms: 2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine;2',3'-dideoxy-2',3'-didehydro-beta-D-5-fluorocytidine;2',3'-dideoxy-2',3'-didehydro-beta-L-5-fluorocytidine;2(1H)-Pyrimidinone, 4-amino-1-((2S,5R)-2,5-dihydro-5-(hydroxymethyl)-2-furanyl)-5-fluoro-;4-amino-5-
• Molecular Weight: 227.19
• Reaxy-Rn: 24713405
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24713405&ln=