Diethyl pyrocarbonate (DEPC) - Moligand™,≥97% , CAS No.1609-47-8

CAS: 1609-47-8 Cat. No.: D137738 Formula: C6H10O5 Peso molecolare: 162.14 Beilstein Registry Number: 637031 Numero EC: 216-542-8
Disponibile su ordine
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
Synonyms
DEP | 3,3',5,5'-tetraethylbenzidine | Diethyl ester of pyrocarbonic acid | diethyl pyrocarbonate | InChI=1/C6H10O5/c1-3-9-5(7)11-6(8)10-4-2/h3-4H2,1-2H | Diethylpyrocarbonate | diethyl-pyrocarbonate | carbonic acid, ethoxycarbonyl ethyl ester | CAS-1609-4
Storage
Store at 2-8°C,Argon charged
Shipped In
Wet ice
★
Size
Germania (EU)
USA*
Price
Qty
5g
D137738-5g
—
9 Disponibile
8,59€
10g
D137738-10g
—
5 Disponibile
9,46€
25g
D137738-25g
—
4 Disponibile
15,53€
100g
D137738-100g
—
3 Disponibile
37,23€
500g
D137738-500g
—
1 Disponibile
164,78€
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™,≥97% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 46 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Panoramica

Diethyl Pyrocarbonate has been shown to inhibit ryanodine binding to ryanodine/Ca2+ receptor channels in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. This compound could be useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Diethyl Pyrocarbonate also inhibits PAF Acetylhydrolase (platelet-activating factor acetyl hydrolase), and has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
An inhibitor of ryanodine binding at the ryanodine/Ca2+ channel

Specifications

Sinonimi
DEP | 3,3',5,5'-tetraethylbenzidine | Diethyl ester of pyrocarbonic acid | diethyl pyrocarbonate | InChI=1/C6H10O5/c1-3-9-5(7)11-6(8)10-4-2/h3-4H2,1-2H | Diethylpyrocarbonate | diethyl-pyrocarbonate | carbonic acid, ethoxycarbonyl ethyl ester | CAS-1609-4
Specifiche e purezza
Moligand™,≥97%
Meccanismi biochimici e fisiologici
Inactivates RNase in solution at about 0.1% (v/v), thus protecting RNA against degradation.
Condizioni di conservazione di stoccaggio
Store at 2-8°C,Argon charged
Spedito in
Wet ice
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
Grado
Moligand™
Purezza
≥97%
Nomi e identificatori
Pubchem Sid488179737
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179737
Sorrisi canoniciCCOC(=O)OC(=O)OCC
IUPAC Nameethoxycarbonyl ethyl carbonate
InChIKeyFFYPMLJYZAEMQB-UHFFFAOYSA-N
INCHI1S/C6H10O5/c1-3-9-5(7)11-6(8)10-4-2/h3-4H2,1-2H3
Isomeri SMILES CCOC(=O)OC(=O)OCC
WGK Germania 3
RTECS LQ9350000
Peso molecolare 162.14
Beilstein 637031
Reaxy-Rn 637031
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=637031&ln=

Documentazione

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClasseOrganic carbonic acids and derivatives
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentOrganic carbonic acids and derivatives
Alternative Parents Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAliphatic acyclic compounds
Substituents Carbonic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound
DescrizioneThis compound belongs to the class of organic compounds known as organic carbonic acids and derivatives. These are compounds comprising the organic carbonic acid or a derivative thereof.
External Descriptors a small molecule
Struttura 3D
Modello di struttura chimica interattiva





Obiettivi associati (umani)
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SOAT2 Tchem Acyl coenzyme A:cholesterol acyltransferase 2 (288 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Obiettivi associati (non umani)
Soat1 Acyl coenzyme A:cholesterol acyltransferase 1 (295 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Meccanismi d'azione
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

42 results found

Lot NumberCertificate TypeDataOggetto
H2625077Certificate of AnalysisSep 01, 2026 D137738
F2313808Certificate of AnalysisAug 04, 2026 D137738
E2620365Certificate of AnalysisMay 26, 2026 D137738
E2620369Certificate of AnalysisMay 26, 2026 D137738
G2508069Certificate of AnalysisApr 07, 2026 D137738
F2418367Certificate of AnalysisFeb 05, 2026 D137738
H2501352Certificate of AnalysisAug 05, 2025 D137738
H2501351Certificate of AnalysisAug 05, 2025 D137738
H2501345Certificate of AnalysisAug 05, 2025 D137738
H2501344Certificate of AnalysisAug 05, 2025 D137738
H2501343Certificate of AnalysisAug 05, 2025 D137738
D2621030Certificate of AnalysisAug 05, 2025 D137738
F2313823Certificate of AnalysisApr 18, 2025 D137738
F2418365Certificate of AnalysisApr 08, 2025 D137738
F2418364Certificate of AnalysisApr 08, 2025 D137738
J2210243Certificate of AnalysisJan 14, 2025 D137738
J2210244Certificate of AnalysisJan 14, 2025 D137738
A2305340Certificate of AnalysisJul 17, 2024 D137738
A2305455Certificate of AnalysisJul 17, 2024 D137738
A2305453Certificate of AnalysisJul 17, 2024 D137738
A2305446Certificate of AnalysisJul 17, 2024 D137738
F2313813Certificate of AnalysisJul 10, 2024 D137738
F2418366Certificate of AnalysisJun 21, 2024 D137738
F2418368Certificate of AnalysisJun 21, 2024 D137738
F2313816Certificate of AnalysisApr 11, 2024 D137738
C2127042Certificate of AnalysisApr 07, 2024 D137738
C2127040Certificate of AnalysisApr 07, 2024 D137738
C2127039Certificate of AnalysisApr 07, 2024 D137738
L2108290Certificate of AnalysisMar 18, 2024 D137738
F2313659Certificate of AnalysisMar 14, 2024 D137738
F2313671Certificate of AnalysisMar 14, 2024 D137738
A2305450Certificate of AnalysisMar 07, 2024 D137738
A2305338Certificate of AnalysisJan 12, 2024 D137738
A2305339Certificate of AnalysisOct 18, 2023 D137738
K2108033Certificate of AnalysisJun 14, 2023 D137738
D2408097Certificate of AnalysisJan 09, 2023 D137738
C2127041Certificate of AnalysisOct 21, 2022 D137738
I2219388Certificate of AnalysisSep 22, 2022 D137738
I2219387Certificate of AnalysisSep 22, 2022 D137738
L2108299Certificate of AnalysisSep 13, 2022 D137738
L2108304Certificate of AnalysisSep 13, 2022 D137738
K2025018Certificate of AnalysisAug 09, 2022 D137738

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Proprietà chimiche e fisiche
SolubilitàSoluble in chloroform, ethanol (50% w/w), esters, ketones, and hydrocarbons.Slowly soluble in water with hydrolytic decomposition yielding ethanol and CO2., Soluble in chloroform, ethanol (50% w/w), esters, ketones, and hydrocarbons.Slowly soluble in wate
SensibilitàHeat and Moisture sensitive
Indice di rifrazionen20/D 1.398
Punto di infiammabilità (°F)156.2 °F
Punto di infiammabilità (°C)69℃
Punto di ebollizione (°C)93-94 °C
Peso molecolare162.140 g/mol
XLogP31.400
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass162.053 Da
Monoisotopic Mass162.053 Da
Topological Polar Surface Area61.800 Ų
Heavy Atom Count11
Formal Charge0
Complexity126.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Domande frequenti e articoli
Citations of This Product
Riferimenti
1. Weidong Qin, Junhua Wang, Zhanqiu Tang, Hongyuan Tian, Zhenglong Wu.  (2023)  Tris(2-carboxyethyl)phosphine-mediated immobilization of thiolated DNA on gold nanoclusters and its application in multiplex microRNA detection.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2023.135028]
2. Liu Xiaohan, Li Ping, Wang Helin, Han Li-Li, Yang Kai, Wang Yanhong, Jiang Zhou, Cui Li, Kao Shuh-Ji.  (2023)  Nitrogen fixation and diazotroph diversity in groundwater systems.  ISME Journal,      [PMID:37715043] [10.1038/s41396-023-01513-x]
3. Jing Xu, Yujin Li, Yinbing Liu, Xu Wu, Ke-jing Huang.  (2023)  Ultra-sensitive self-powered sensor based on the hollow Rubik's cube substrate and multiple signal amplification strategy for real-time heavy metal detection.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2023.134377]
4. Zhenxing Cai, Jixiang Liu, Hui Zhao, Lingyan Wang, Xiaobo Chen, Chaohe Yang.  (2023)  Isobaric (Vapor + Liquid) Equilibria for Propylene Carbonate with para-Xylene, ortho-Xylene, meta-Xylene, and Ethylbenzene at 101.33 kPa.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.3c00076]
5. Jing Xu, Yinbing Liu, Ke-Jing Huang, Renjie Wang, Xiaoxuan Sun.  (2023)  An ingenious designed dual mode self-powered biosensing platform based on graphdiyne heterostructure substrate for instant hepatocarcinoma marker detection.  TALANTA,      [PMID:37209584] [10.1016/j.talanta.2023.124656]
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9. Liuwei Zhang, Jingyun Wang, Hongyan Cui, Haonan Zheng, Xiaolan Yin, Jiaqi Lin, Yue Wang, Yan Zhao, Haidong Li, Qixian Chen.  (2023)  Simultaneous Knockdown of Immune Suppressive Markers by Tumor Microenvironment-Responsive Multifaceted Prodrug Nanomedicine.  ACS Applied Materials & Interfaces,      [PMID:36856003] [10.1021/acsami.3c00986]
10. Zhenxing Cai, Gengfei Yang, Hui Zhao, Xiaobo Chen, Chaohe Yang.  (2023)  Isobaric (Vapor + Liquid) Equilibria for Methylcyclohexane with Para-, Ortho-, and Meta-Xylenes and Ethylbenzene at 101.33 kPa.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.2c00715]
11. Chengjie Duan, Yan Chen, Zhiqiang Hou, Dayong Li, Jin Jiao, Weihao Sun, Yang Xiang.  (2023)  Heteromultivalent scaffolds fabricated by biomimetic co-assembly of DNA–RNA building blocks for the multi-analysis of miRNAs.  Journal of Materials Chemistry B,  11  (7): (1478-1485).  [PMID:36723144] [10.1039/D2TB02663E]
12. Fu-Ting Wang, Yang-Yang Hou, Xuecai Tan, Ke-Jing Huang, Jing Xu, Ren Cai.  (2022)  Real-time multiple signal amplification self-powered biosensing platform for ultrasensitive detection of MicroRNA.  BIOSENSORS & BIOELECTRONICS,      [PMID:36470063] [10.1016/j.bios.2022.114933]
13. Fu Gafang, Gao Chenxi, Quan Kaijun, Li Hui, Qiu Hongdeng, Chen Jia.  (2022)  Phosphorus-doped deep eutectic solvent-derived carbon dots-modified silica as a mixed-mode stationary phase for reversed-phase and hydrophilic interaction chromatography.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  415  (18): (4255-4264).  [PMID:36350343] [10.1007/s00216-022-04405-9]
14. Qing Liu, Xin Fang, Zeng-Ping Chen, Cai-Xia Shi, Ru-Qin Yu.  (2022)  Quantification of miRNAs by mass spectrometry based on DNase I-assisted amplification with the aid of a chemometric model.  CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS,      [PMID:] [10.1016/j.chemolab.2022.104603]
15. Fu-Ting Wang, Hu Luo, Yang-Yang Hou, Yu Ya, Ke-Jing Huang, Shu-Peng Li, Lan-Rui Wang, Ya-Lin Song, Xuecai Tan.  (2022)  Dual microRNAs-driven enzyme biofuel cells: Visualization biosensing system with capacitor assistance output signal amplification.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2022.131970]
16. Xiaoping Wu, Qiujie Pang, Fuxiang Zhi, Xiaohong Mao, Yingbin Hu.  (2022)  Overexpression of long non-coding RNA ACTA2-AS1 inhibits the viability, proliferation, migration and invasion of colorectal cancer cells.  TISSUE & CELL,      [PMID:35325674] [10.1016/j.tice.2022.101769]
17. Fu-Ting Wang, Jing Xu, Yang-Yang Hou, Ke-Jing Huang, Xin-Meng Yu, Xin Zhou, Xuecai Tan.  (2022)  Matching Capacitors to Self-Powered Biosensors for Signal Amplification: Toward Ultrasensitive Electrochemical Detection for MicroRNA-21-Triggered Catalytic Hairpin Assembly.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.1c07082]
18. Jingwen Wang, Jing Wang, Shuilai Qiu, Weijian Chen, Liang Cheng, Wenxiang Du, Jinghao Wang, Longfei Han, Lei Song, Yuan Hu.  (2021)  Biodegradable L-lysine-modified amino black phosphorus/poly(l-lactide-coε-caprolactone) nanofibers with enhancements in hydrophilicity, shape recovery and osteodifferentiation properties.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:34814101] [10.1016/j.colsurfb.2021.112209]
19. Zhenxing Cai, Hui Zhao, Xin Zhou, Xiaobo Chen, Chaohe Yang.  (2021)  Determination and modeling of binary solid-liquid equilibria of para-xylene/meta-xylene, para-xylene/ortho-xylene by DSC method.  FLUID PHASE EQUILIBRIA,      [PMID:] [10.1016/j.fluid.2021.113325]
20. Liping Yang, Jiacheng Xing, Danhua Yuan, Lin Li, Yunpeng Xu, Zhongmin Liu.  (2021)  Synthesis of high-crystallinity MIL-125 with outstanding xylene isomer separation performance.  CHINESE JOURNAL OF CATALYSIS,      [PMID:] [10.1016/S1872-2067(21)63905-0]
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25. Zhao Chen, Hong Cheng-yi, Lin Zheng-zhong, Chen Xiao-mei, Huang Zhi-Yong.  (2019)  Detection of Malachite Green using a colorimetric aptasensor based on the inhibition of the peroxidase-like activity of gold nanoparticles by cetyltrimethylammonium ions.  MICROCHIMICA ACTA,  186  (5): (1-8).  [PMID:31049692] [10.1007/s00604-019-3436-3]
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37. Weihong Yin, Kai Hu, Bingwen Yu, Tao Zhang, Haohua Mei, Bowen Zhang, Zheyu Zou, Liping Xia, Yehong Gui, Juxin Yin, Wei Jin, Ying Mu.  (2024)  Fast and sensitive detection of viable Escherichia coliO157:H7 using microwell confined and propidium monoazide assisted digital CRISPR microfluidic platform.  LAB ON A CHIP,      [PMID:39228336] [10.1039/D4LC00672K]
38. De Bai, Haowei Chen, Nanxi Xiang, Chunqiao Zhang, Zhenyuan Wang, Jichuan Zhang, Chengyu Wu, Fang Wang, Jiaheng Zhang.  (2024)  Ionic liquid combined with cationic liposome co-delivers microphthalmia-associated transcription factor small interfering RNA to regulate melanogenesis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39332571] [10.1016/j.ijbiomac.2024.136027]
39. Luyun Xu, Yuanmei Chen, Jianqing Ye, Min Fan, Guibin Weng, Yongshi Shen, Zhizhong Lin, Duo Lin, Yuanji Xu, Shangyuan Feng.  (2024)  Optical Nanobiosensor Based on Surface-Enhanced Raman Spectroscopy and Catalytic Hairpin Assembly for Early-Stage Lung Cancer Detection via Blood Circular RNA.  ACS Sensors,      [PMID:38602529] [10.1021/acssensors.3c02810]
40. Lei Ruiwen, Yao Chaoling, Huang Renfeng, Wu Wanming, Ou Linyang, Yang Chuansheng.  (2024)  STC2 suppresses triple-negative breast cancer migration and invasion by inhibition on EMT and promotion on cell apoptosis.  Discover Oncology,  15  (1): (1-13).  [PMID:39117970] [10.1007/s12672-024-01196-6]
41. Hong Tao, Shuyun Weng, Luyun Xu, Jianqing Ye, Min Fan, Yong Wang, Yao Lin, Duo Lin, Qingshui Wang, Shangyuan Feng.  (2024)  Target-triggered assembly of plasmon resonance nanostructures for quantitative detection of lncRNA in liver cancer cells via surface enhanced Raman spectroscopy.  BIOSENSORS & BIOELECTRONICS,      [PMID:38905860] [10.1016/j.bios.2024.116488]
42. Jing Xu, Yinbing liu, Xinqi Luo, Yujin Li, Yiqing Xing, Ke-Jing Huang.  (2024)  Visual self-powered platform for ultrasensitive heavy metal detection designed on graphdiyne/graphene heterojunction and DNAzyme-triggered DNA circuit strategy.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.150151]
43. Luyun Xu, Yongshi Shen, Zhizhong Lin, Jianqing Ye, Lingna Wang, Xueliang Lin, Shuhang Liu, Duo Lin, Yuanji Xu, Zongyang Yu, Rongcai Zhang, Shangyuan Feng.  (2025)  A catalytic hairpin assembly-assisted magnetic SERS platform with core-satellite structure for ultra-sensitive circRNA detection in early lung cancer screening.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.163309]
44. Weidong Chen, Zelin Yang, Yuheng Luo, Jianxun Huang, Lijie Wu, Wenxiong Liu, Yifei Wang, Jiajia Wu, Yining Li, Fang Sun, Pengming Song, Baoce Sun, Qiang Xu.  (2025)  Flowthrough thermal regulation enables ultrafast real-time PCR.  Cell Reports Physical Science,      [PMID:] [10.1016/j.xcrp.2025.103052]
45. Kan Yang, Changan Cheng, Youjia Zhang, Zhaoying Liu, Enze Sheng, Zhen Zhang, Ming Li.  (2026)  Tri-mode fluorescence/colorimetric/strip aptasensor with CRISPR/Cas12a-driven cascade strategy for mycotoxin.  Current Research in Food Science,      [PMID:41568343] [10.1016/j.crfs.2026.101303]
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