Dihydromyricetin - analytical standard, ≥98% , CAS No.27200-12-0

CAS: 27200-12-0 Cat. No.: D101549 Molecular Weight: 320.25 EC Number: 814-912-9
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GRADE & PURITY Analytical standard ? Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods. ≥98%
Synonyms
(2R,3R)-2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one | HY-N0112 | Dihydromyricetin (Ampeloptin) | SW219328-1 | (+)-Dihydromyricetin | AKOS022168215 | AS-71702 | Dihydromyricetin | dihydro-myricetin | Dihydromyricetin, anal
Storage
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20mg
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D101549-100mg
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500mg
D101549-500mg
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1g
D101549-1g
2
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D101549-5g
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Why this grade

analytical standard, ≥98% Analytical standard for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 32 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
(2R, 3R)-2, 3-dihydro-3, 5, 7-trihydroxy-2-(3, 4, 5-trihydroxyphenyl)-4H-1-benzopyran-4-one | HY-N0112 | Dihydromyricetin (Ampeloptin) | SW219328-1 | (+)-Dihydromyricetin | AKOS022168215 | AS-71702 | Dihydromyricetin | dihydro-myricetin | Dihydromyricetin, anal
Specifications & Purity
analytical standard, ≥98%
Storage
Room temperature
Shipped In
Normal
Grade
Analytical standard
Purity
≥98%
Names and Identifiers
Canonical SmilesC1=C(C=C(C(=C1O)O)O)C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O
IUPAC Name(2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
InChIKeyKJXSIXMJHKAJOD-LSDHHAIUSA-N
INCHI1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
Isomeric SMILES C1=C(C=C(C(=C1O)O)O)[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O
WGK Germany 3
Molecular Weight 320.25
Reaxy-Rn 332335
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=332335&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
ClassFlavonoids
SubclassFlavans
Intermediate Tree Nodes Flavan-3-ols - Catechins
Direct ParentEpigallocatechins
Alternative Parents 3'-hydroxyflavonoids  3-hydroxyflavonoids  4'-hydroxyflavonoids  5-hydroxyflavonoids  Flavanonols  7-hydroxyflavonoids  Chromones  Pyrogallols and derivatives  Aryl alkyl ketones  1-hydroxy-2-unsubstituted benzenoids  1-hydroxy-4-unsubstituted benzenoids  Alkyl aryl ethers  Benzene and substituted derivatives  Vinylogous acids  Secondary alcohols  Oxacyclic compounds  Polyols  Hydrocarbon derivatives  Organic oxides  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Epigallocatechin - 3'-hydroxyflavonoid - 3-hydroxyflavonoid - 4'-hydroxyflavonoid - 5-hydroxyflavonoid - 7-hydroxyflavonoid - Flavanone - Flavanonol - Hydroxyflavonoid - Chromone - Chromane - Benzopyran - 1-benzopyran - Benzenetriol - Pyrogallol derivative - Aryl alkyl ketone - Aryl ketone - Phenol - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - 1-hydroxy-4-unsubstituted benzenoid - Benzenoid - Monocyclic benzene moiety - Vinylogous acid - Ketone - Secondary alcohol - Polyol - Ether - Organoheterocyclic compound - Oxacycle - Alcohol - Hydrocarbon derivative - Organooxygen compound - Organic oxygen compound - Organic oxide - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as epigallocatechins. These are compounds containing epigallocatechin or a derivative. Epigallocatechin is a flavan-3-ol containing a benzopyran-3,5,7-triol linked to a 3,4,5-hydroxyphenyl moiety.
External Descriptors Dihyroflavonols
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
APP Tclin Amyloid-beta A4 protein (8510 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-2 (46422 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-OV-3 (52876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BT-549 (31254 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SYNJ2 Tchem Synaptojanin-2 (76 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C6 (2371 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BV-2 (3710 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeDateItem
E2606072Certificate of AnalysisMay 12, 2026 D101549
B2208258Certificate of AnalysisAug 07, 2025 D101549
B2208259Certificate of AnalysisAug 07, 2025 D101549
B2208262Certificate of AnalysisAug 07, 2025 D101549
B2208264Certificate of AnalysisAug 07, 2025 D101549
B2208351Certificate of AnalysisAug 07, 2025 D101549
G2503022Certificate of AnalysisJul 14, 2025 D101549
B2006101Certificate of AnalysisSep 06, 2023 D101549
K1822067Certificate of AnalysisJun 22, 2022 D101549
B2208260Certificate of AnalysisAug 05, 2021 D101549
Chemical and Physical Properties
Specific Rotation[α]+15.5 to +17.0 deg(C=0.9, methanol)
Melt Point(°C)248 °C
Molecular Weight320.250 g/mol
XLogP31.100
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count8
Rotatable Bond Count1
Exact Mass320.053 Da
Monoisotopic Mass320.053 Da
Topological Polar Surface Area148.000 Ų
Heavy Atom Count23
Formal Charge0
Complexity445.000
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Chengyun He, Lu Bai, Daqun Liu, Benguo Liu.  (2023)  Interaction mechanism of okra (Abelmoschus esculentus L.) seed protein and flavonoids: Fluorescent and 3D-QSAR studies.  Food Chemistry-X,      [PMID:38144792] [10.1016/j.fochx.2023.101023]
2. Mingxiang Lu, Renzhi Liu, Zhifei Chen, Chen Su, Luqing Pan.  (2023)  Effects of dietary dihydromyricetin on growth performance, antioxidant capacity, immune response and intestinal microbiota of shrimp (Litopenaeus vannamei).  FISH & SHELLFISH IMMUNOLOGY,      [PMID:37722436] [10.1016/j.fsi.2023.109086]
3. Dongqing Zhang, Wenqi Liu, Ke Ye, Xiaojin Li.  (2023)  High CO and sulfur tolerant proton exchange membrane fuel cell anodes enabled by “work along both lines” mechanism of 2,6-dihydroxymethyl pyridine molecule blocking layer.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:37722170] [10.1016/j.jcis.2023.09.076]
4. Shiyu Zhen, Sheng Geng, Hanjun Ma, Benguo Liu.  (2022)  Interaction of α-lactalbumin with dihydromyricetin and its application in nano-emulsion.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  58  (3): (1120-1129).  [PMID:] [10.1111/ijfs.16255]
5. Songqi Liu, Zaihan Chen, Huange Zhang, Yuanli Li, Taxipalati Maierhaba, Jianhui An, Zhi Zhou, Lingli Deng.  (2022)  Comparison of eugenol and dihydromyricetin loaded nanofibers by electro-blowing spinning for active packaging.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2022.102294]
6. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang.  (2022)  Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin.  Food & Function,  13  (9): (5061-5074).  [PMID:35404372] [10.1039/D1FO03816H]
7. Xu Jinfang, Li Xinying, Xu Yaqin, Wang Anqi, Xu Zhilang, Wu Xia, Li Defu, Mu Changdao, Ge Liming.  (2021)  Dihydromyricetin-Loaded Pickering Emulsions Stabilized by Dialdehyde Cellulose Nanocrystals for Preparation of Antioxidant Gelatin–Based Edible Films.  Food and Bioprocess Technology,  14  (9): (1648-1661).  [PMID:] [10.1007/s11947-021-02664-5]
8. Qian Zhou, Jia-Yi Yin, Wei-Yue Liang, Dong-Mei Chen, Qing Yuan, Bao-long Feng, Ying-Hua Zhang, Yu-Tang Wang.  (2021)  Various machine learning approaches coupled with molecule simulation in the screening of natural compounds with xanthine oxidase inhibitory activity.  Food & Function,  12  (4): (1580-1589).  [PMID:33470259] [10.1039/D0FO03059G]
9. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song.  (2020)  Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:32480277] [10.1016/j.saa.2020.118519]
10. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang.  (2020)  Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations.  FOOD CHEMISTRY,      [PMID:32330646] [10.1016/j.foodchem.2020.126807]
11. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu.  (2019)  Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies.  Foods,  (9): (355).  [PMID:31438605] [10.3390/foods8090355]
12. Hao Liu, Wenmei Zhao, Qi Hu, Ling Zhao, Yumeng Wei, Chao Pi, Yuhan Yang, Xuerong Yang, Hang Yuan, Yuhan Zhang, Kunyan Qu, Xinyu Shi, Yao Huang, Houyin Shi.  (2019)  Gastric floating sustained-release tablet for dihydromyricetin: Development, characterization, and pharmacokinetics study.  SAUDI PHARMACEUTICAL JOURNAL,      [PMID:31997907] [10.1016/j.jsps.2019.08.002]
13. Meihui Fan, Huafang Ding, Guowen Zhang, Xing Hu, Deming Gong.  (2019)  Relationships of dietary flavonoid structure with its tyrosinase inhibitory activity and affinity.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2019.02.076]
14. Han Peng, Zeyuan Deng, Xuan Chen, Yong Sun, Bing Zhang, Hongyan Li.  (2018)  Major chemical constituents and antioxidant activities of different extracts from the peduncles of Hovenia acerba Lindl.  INTERNATIONAL JOURNAL OF FOOD PROPERTIES,      [PMID:] [10.1080/10942912.2018.1497059]
15. Umair Muhammad, Hedong Lu, Juan Wang, Jinzhi Han, Xiaoyu Zhu, Zhaoxin Lu, Sultana Tayyaba, Yousef I. Hassan.  (2017)  Optimizing the Maximum Recovery of Dihydromyricetin from Chinese Vine Tea, Ampelopsis grossedentata, Using Response Surface Methodology.  MOLECULES,  22  (12): (2250).  [PMID:29258286] [10.3390/molecules22122250]
16. Han Peng, Wenting Li, Hongyan Li, Zeyuan Deng, Bing Zhang.  (2017)  Extractable and non-extractable bound phenolic compositions and their antioxidant properties in seed coat and cotyledon of black soybean (Glycinemax (L.) merr).  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2017.03.003]
17. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan.  (2016)  The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum.  FOOD CHEMISTRY,      [PMID:28159264] [10.1016/j.foodchem.2016.12.001]
18. Shimei Qi, Xianjuan Kou, Jun Lv, Zhilin Qi, Liang Yan.  (2015)  Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways: Involvement of P38 and ERK.  ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,      [PMID:26476886] [10.1016/j.etap.2015.09.015]
19. Shian Zhong, Yanyue Kong, Ling Zhou, Chengyun Zhou, Xiaona Zhang, Yan Wang.  (2013)  Efficient conversion of myricetin from Ampelopsis grossedentata extracts and its purification by MIP-SPE.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,      [PMID:24321759] [10.1016/j.jchromb.2013.11.036]
20. Fei Wang, Xiang Yu, Haojie Li, Ming Li, Qimin Feng.  (2013)  Graphene-Nafion Composite Film Modified Electrode for Voltammetric Sensor for Determination of Dihydromyricetin.  JOURNAL OF THE CHINESE CHEMICAL SOCIETY,  60  (8): (1019-1026).  [PMID:] [10.1002/jccs.201300020]
21. Yimei Zheng, Boyu Chen, Xuanxiang Huang, Xiamei Tao, Chao Ai, Yanan Zhao, Peng Liang, Lei Chen.  (2024)  A designed self-microemulsifying delivery system: Stability and Anti-inflammation in vivo enhancement of dihydromyricetin.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2024.106266]
22. Yucan Zhang, Chenxi Shi, Jin Yuan, Yue Zhang, Xiaohui Jin, Shaopo Zu, Honglei Zhang, Hui Hu.  (2024)  Rapid Construction of Recombinant PDCoV Expressing an Enhanced Green Fluorescent Protein for the Antiviral Screening Assay Based on Transformation-Associated Recombination Cloning in Yeast.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:38181302] [10.1021/acs.jafc.3c08327]
23. Mingxiang Lu, Futao Jing, Renzhi Liu, Zhifei Chen, Ruixue Tong, Yaobing Li, Luqing Pan.  (2024)  The effects and mechanisms of dietary ferulic acid (FA) and dihydromyricetin (DMY) on growth and physiological responses of the shrimp (Litopenaeus vannamei).  AQUACULTURE,      [PMID:] [10.1016/j.aquaculture.2024.740967]
24. Chao-Yue Sun, Wan-Qing Li, Jing-Wen Lu, Ao-Yue Zhang, Qing-Xia Chu, Li Tang, Wei Gao, Jin-Jie Cai, Ying Lu, Dong Liu.  (2025)  Ampelopsis grossedentata protects against ethanol-induced acute duodenal injury by inhibiting TNF-triggered caspases-dependent apoptosis in mice.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:40854417] [10.1016/j.jep.2025.120462]
25. Yi Wu, Shuohan He, Meng Li, Yan Li, Shaopeng Liu, Hongwei Xiong, Qianxiang Meng, Peng Liu, Kaiyong Cai.  (2025)  Breaking Age-Impaired Bone Healing Challenge: Smart Hydrogel-Coated Implant Reprograms Aging Bone Microenvironments via Senolytic and Pro-Angiogenic Dual Therapy.  Advanced Healthcare Materials,      [PMID:40947643] [10.1002/adhm.202501928]
26. Xiaojing Si, Yue Huang, Mei Han, Liqiang Luo.  (2025)  Electrochemical Sensor Based on Co-MOF for the Detection of Dihydromyricetin in Ampelopsis grossedentata.  MOLECULES,  30  (1): (180).  [PMID:39795236] [10.3390/molecules30010180]
27. Yuwen Guan, Qiuyue Lv, Xinyu Wang, Baoping Jiang, Peigen Xiao.  (2025)  Dihydromyricetin as a Dietary Supplement Enhances Hypoglycemic Efficacy: Synergistic Modulation of the Gut-Liver with Sangzhi Alkaloids.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.106197]
28. Ze-Rui Sun, Hui-Zhen Peng, Mao-Si Fan, Dong Chang, Ming-Yue Wang, Meng-Fei An, Li-Juan Zhang, Rui Zan, Jun Sheng, Yun-Li Zhao, Xuan-Jun Wang.  (2025)  Dihydromyricetin ameliorates hyperuricemia through inhibiting uric acid reabsorption.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,      [PMID:40202030] [10.1002/jsfa.14126]
29. Jia Li, Lijia Li, Tahui Lin, Houtan Huang, Jie Ren, Jengyuan Yao.  (2025)  Dihydromyricetin preserves β-cell function in type 1 diabetes via PI3K/AKT-mediated metabolic reprogramming.  Frontiers in Nutrition,      [PMID:41112749] [10.3389/fnut.2025.1682308]
30. Ling Tang, Jinqing Chen, Jiali Luo, Huijuan Wei, Lina Lan, Hailan Qin, Qiumei He, Xiangyu Kong, Liting Lai, Wenya Ding, Jian Xiao.  (2025)  Dihydromyricetin-loaded TPGS/gelatin grafted-β-Cyclodextrin/ chitosan grafted-β-Cyclodextrin nano-delivery system for improving oral absorption.  FOOD RESEARCH INTERNATIONAL,      [PMID:41652702] [10.1016/j.foodres.2025.118296]
31. Gerui Ren, Ruiqi Hu, Jiajun Mao, Xinpei Cai, Tianrong Wang, Xin Song, Wentao Wu, Caixin Zhuge, Min Huang, Hujun Xie, Kejun Cheng.  (2026)  From poor solubility to precision delivery: Zein–κ-carrageenan nanovehicles unlock dihydromyricetin's bioactive potential.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:41708022] [10.1016/j.ijbiomac.2026.150961]
32. Shen Yemei, Gao Xuemei, Huan Xuanrong, He Cui, Liu Yu, Li Yuan.  (2026)  Dihydromyricetin exhibits potent antiplatelet activity with minimal impact on coagulation system: an in vitro study.  BLOOD COAGULATION & FIBRINOLYSIS,      [PMID:41693263] [10.1097/MBC.0000000000001416]
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