Diltiazem HCl - 10mM in DMSO , CAS No.33286-22-5

CAS: 33286-22-5 Cat. No.: D408398 Formula: C₂₂H₂₆N₂O₄S·HCl Peso molecolare: 450.98 Numero EC: 251-443-3

GRADE & PURITY 10mM in DMSO

Synonyms

RG 83606 HCl | (2S,​3S)​- 3-​(acetyloxy)​-​5-​[2-​(dimethylamino)​ethyl]​-​2,​3-​dihydro-​2-​(4-​methoxyphenyl)​-1,​5-​benzothiazepin-​4(5H)​-​one,hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Diltiazem HCl Diltiazem (Tiazac, RG 83606) HCl is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.
In vitro

In vivo

Cell Data

cell lines：HCT116, HCT116 p53−/−, EW36, BL2, NTera2D, NTera2D-DNp53, ARN8, NHDF, SKNH-pCMV and SKNSH-DNp53.

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

RG 83606 HCl | (2S,​3S)​- 3-​(acetyloxy)​-​5-​[2-​(dimethylamino)​ethyl]​-​2,​3-​dihydro-​2-​(4-​methoxyphenyl)​-1,​5-​benzothiazepin-​4(5H)​-​one,hydrochloride (1:1)

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Diltiazem (Tiazac, RG 83606) HCl is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

• Isomeri SMILES: CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl
• WGK Germania: 3
• RTECS: DL0310000
• CAS alternativo: 42399-41-7
• Peso molecolare: 450.98
• Reaxy-Rn: 6889420
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6889420&ln=

Proprietà chimiche e fisiche

• Rotazione specifica [α]: 114 to 122 deg(C=1, H2O)
• Punto di fusione (°C): 210 °C

Riferimenti

1. Wang Yiran, Shi Jihua, Dai Dapeng, Cai Jianping, Wang Shuanghu, Hong Yun, Zhou Shan, Zhao Fangling, Zhou Quan, Geng Peiwu, Zhou Yunfang, Xu Xue, Luo Qingfeng.  (2022)  Evaluation of commonly used cardiovascular drugs in inhibiting vonoprazan metabolism in vitro and in vivo.  Frontiers in Pharmacology,      [PMID:36052128] [10.3389/fphar.2022.909168]