Diphemanil Methylsulfate - 10mM in DMSO , Muscarinic acetylcholine receptor M1 antagonist, CAS No.62-97-5, Muscarinic acetylcholine receptor M1 antagonist

CAS: 62-97-5 Cat. No.: D409097 Formula: C₂₁H₂₇NO₄OS Peso molecolare: 405.51 Numero EC: 200-552-4

GRADE & PURITY 10mM in DMSO

Synonyms

Piperidinium, 4-(diphenylmethylene)-1,1-dimethyl-, methyl sulfate (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).
In vitro

Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. In addition to its well known antimuscarinic effects, Diphemanil Methylsulfate also possesses direct smooth musclespasmolytic activity.

In vivo

The pharmacokinetic experiments show that absorption of diphemanil methylsulphate is slow (tmax = 2 to 4 h), the mean half-life is 8.35 h, and the amount of the drug recovered in urine within 48 h ranges from 0.6 to 7.4% of the administered dose. Poorly absorbed from the gastrointestinal tract with an absolute bioavailability of 15 to 25%.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

Piperidinium, 4-(diphenylmethylene)-1,1-dimethyl-, methyl sulfate (1:1)

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

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Tipo di azione

ANTAGONIST

Meccanismo d'azione

Muscarinic acetylcholine receptor M1 antagonist

Nomi e identificatori

• Isomeri SMILES: C[N+]1(CCC(=C(C2=CC=CC=C2)C3=CC=CC=C3)CC1)C.COS(=O)(=O)[O-]
• RTECS: TN5075000
• Peso molecolare: 405.51
• Reaxy-Rn: 3842254
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3842254&ln=

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 34 mg/mL (113.92 mM); Ethanol: 28 mg/mL (93.81 mM); Water: Insoluble
• Punto di fusione (°C): 194 °C