DSPE PEG, mPEG-DSPE - MW 2000 Da , CAS No.147867-65-0

CAS: 147867-65-0 Cat. No.: D163634 Formula: (C₂H₄O)nC₄₃H₈₄NO₁₀P

GRADE & PURITY MW 2000 Da

Storage

Al riparo dalla luce, conservare a -20°C, carica di argon

Shipped In

Cassetta del ghiaccio + cuscini per il ghiaccio

Application

Drug Delivery, Surface Modification, PEGylation of Protein, Peptide & Oligo

Panoramica

il polietilenglicole coniugato con 1,2-distearoil-sn-glicero-3-fosfoetanolammina (DSPE), DSPE PEG, è un fosfolipide coniugato con PEG che possiede sia idrofilia che idrofobilità. I fosfolipidi pegilati sono eccellenti materiali per la formazione di liposomi che possono essere utilizzati anche per la somministrazione di farmaci, la trasfezione genica e la somministrazione di vaccini. La pegilazione dei fosfolipidi migliora significativamente la durata della circolazione sanguigna e la stabilità dei farmaci incapsulati. Questi materiali possono essere utilizzati anche per la somministrazione mirata di farmaci, modificando la loro superficie con ligandi di targeting come anticorpi e peptidi.

Specifications

Specifiche e purezza

MW 2000 Da

Condizioni di conservazione di stoccaggio

Al riparo dalla luce, conservare a -20°C, carica di argon

Spedito in

Cassetta del ghiaccio + cuscini per il ghiaccio

Nomi e identificatori

• Pubchem Sid: 488202412
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488202412
• Sorrisi canonici: CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCCNC(=O)OCCOC)OC(=O)CCCCCCCCCCCCCCCCC.[Na+]
• IUPAC Name: sodium;[(2R)-2,3-di(octadecanoyloxy)propyl] 2-(2-methoxyethoxycarbonylamino)ethyl phosphate
• InChIKey: SRLOHQKOADWDBV-NRONOFSHSA-M
• INCHI: 1S/C45H88NO11P.Na/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-43(47)54-40-42(41-56-58(50,51)55-37-36-46-45(49)53-39-38-52-3)57-44(48)35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-5-2;/h42H,4-41H2,1-3H3,(H,46,49)(H,50,51);/q;+1/p-1/t42-;/m1./s1
• Isomeri SMILES: CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCCNC(=O)OCCOC)OC(=O)CCCCCCCCCCCCCCCCC.[Na+]
• Reaxy-Rn: 60733557
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=60733557&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Classe Glycerophospholipids
      • Subclass Glycerophosphoethanolamines
        • Level5 Glycero-3-phospho-N-acyl-ethanolamines
          • Level6 N-acyl-phosphatidylethanolamines

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Classe: Glycerophospholipids
• Subclass: Glycerophosphoethanolamines
• Intermediate Tree Nodes: Glycero-3-phospho-N-acyl-ethanolamines
• Direct Parent: N-acyl-phosphatidylethanolamines
• Alternative Parents: Phosphoethanolamines Fatty acid esters Dialkyl phosphates Dicarboxylic acids and derivatives Carbamate esters Carboxylic acid esters Dialkyl ethers Organonitrogen compounds Organic sodium salts Organic oxides Hydrocarbon derivatives Carbonyl compounds Organic cations
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: N-acyl-phosphatidylethanolamine - Phosphoethanolamine - Fatty acid ester - Dialkyl phosphate - Dicarboxylic acid or derivatives - Organic phosphoric acid derivative - Phosphoric acid ester - Fatty acyl - Alkyl phosphate - Carbamic acid ester - Carboxylic acid ester - Organic alkali metal salt - Ether - Dialkyl ether - Carboxylic acid derivative - Organic salt - Organic sodium salt - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Organic cation - Aliphatic acyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as n-acyl-phosphatidylethanolamines. These are phosphatidylethanolamines with a N-acylated ethanolamine moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Proprietà chimiche e fisiche

• Solubilità: Off-white/white solid or semi-solid depends on molecule weight;Soluble in warm water and chloroform
• Sensibilità: light & moisture & heat sensitive
• Peso molecolare: 872.100 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 48
• Exact Mass: 871.591 Da
• Monoisotopic Mass: 871.591 Da
• Topological Polar Surface Area: 159.000 Ų
• Heavy Atom Count: 59
• Formal Charge: 0
• Complexity: 994.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Riferimenti

1. Zhenhu Guo, Xiaohan Gao, Jingsong Lu, Ying Li, Zeping Jin, Abdul Fahad, Neema Ufurahi Pambe, Hirotaka Ejima, Xiaodan Sun, Xiumei Wang, Wensheng Xie, Guifeng Zhang, Lingyun Zhao.  (2024)  Apoptosis and Paraptosis Induced by Disulfiram-Loaded Ca2+/Cu2+ Dual-Ions Nano Trap for Breast Cancer Treatment.  ACS Nano,      [PMID:38377439] [10.1021/acsnano.3c10173]

2. Beibei Zhang, Hao Liu, Yifei Wang, Yong Zhang.  (2024)  ROS-Responsive and Self-Catalytic Nanocarriers for a Combination of Chemotherapy and Reinforced Ferroptosis against Breast Cancer.  ACS Biomaterials Science & Engineering,      [PMID:39262329] [10.1021/acsbiomaterials.4c01233]

3. Yang Qihao, Wu Jianqun, Huang Songqiang, Zeng Jing, Jing Yihan, Wang Zhiyong, Zhang Chi, Wu Zenghui, Liu Song, Wang Zhao.  (2025)  Eicosapentaenoic acid restores inflammation-induced changes in chondrocyte mechanics by suppressing the NF-κB p65/CD44 signaling pathway and attenuates osteoarthritis.  EXPERIMENTAL AND MOLECULAR MEDICINE,      [PMID:40887495] [10.1038/s12276-025-01529-7]

4. Fangxue Du, Hongxin Zhao, Ruiqian Guo, Jianbo Huang, Ziyan Feng, Ziyao Wang, Li Qiu.  (2025)  Nature-based nanothylakoids for reshaped tumor microenvironment-assisted robust sonodynamic immunotherapy.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.171503]